Association between lactate concentration in amniotic fluid and dysfunctional labor

Acta Obstetricia Et Gynecologica Scandinavica
Eva Wiberg-ItzelL Nordström

Abstract

To assess whether there is an association between high lactate concentration in amniotic fluid (AF) and labor dystocia. Prospective observational study. Labor ward at General South Hospital, Stockholm, Sweden. Women in active labor attending labor ward, having at least two consecutive measurements of lactate concentration in AF, measured 60 minutes apart. Dysfunctional labor, defined as instrumental or operative delivery due to dystocia. Among women with spontaneous vaginal deliveries (n=23) the mean lactate concentration in AF during labor was 8.9 mmol/l (range 6.6-10.8), and among women with operative delivery due to labor dystocia (n=31) the corresponding value was 10.9 mmol/l (range 8.0-16.1) (p<0.001). Of 29 women with a high lactate concentration (> or =10.1 mmol/l) in at least two consecutive measures collected at least 60 minutes apart, 25 (86%) were delivered instrumentally/operatively due to dystocia. Using this definition of a positive test, the diagnostic accuracy to predict operative delivery due to dystocia was: sensitivity 81% (25/31), specificity 83% (19/23), positive predictive value 86% (25/29), and negative predictive value 76% (19/25). The likelihood ratio was 5.0 for a positive test and 0.2 for a negative t...Continue Reading

Citations

Oct 1, 2014·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Zekiye KaraçamGeorge John Bugg
Jun 15, 2010·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Eva Wiberg-ItzelHelena Akerud
Jun 22, 2011·Obstetrics and Gynecology·Eva Wiberg-ItzelUlla-Britt Wennerholm
Jun 28, 2015·American Journal of Obstetrics and Gynecology·Martina MurphyMichael Robson
Oct 10, 2013·Acta Obstetricia Et Gynecologica Scandinavica·Eva Wiberg-ItzelHelena Åkerud
Dec 10, 2013·Experimental Physiology·Sarah ArrowsmithSusan Wray
Dec 3, 2014·Acta Physiologica·S WrayS Arrowsmith
Sep 13, 2016·American Journal of Obstetrics and Gynecology·Ankush MadaanSylvain Chemtob
Jun 8, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Eva Wiberg-ItzelHelena Åkerud
Apr 25, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Irene SterpuEva Wiberg-Itzel
Oct 15, 2009·American Journal of Physiology. Endocrinology and Metabolism·Helena AkerudEva Wiberg-Itzel
Oct 30, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Venance Basil-KwayAntonio Gordillo-Moscoso

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