Association between left ventricular diastolic function and right ventricular function and morphology in asymptomatic aortic stenosis

PloS One
Nicolaj Lyhne ChristensenJacob Eifer Møller

Abstract

Aortic stenosis (AS) is a progressive disease in which left ventricular (LV) diastolic dysfunction is common. However, the association between diastolic dysfunction and right ventricular (RV) loading conditions and function has not been investigated in asymptomatic AS patients. A total of 41 patients underwent right heart catheterization and simultaneous echocardiography at rest and during maximal supine exercise, stratified according to resting diastolic function. Cardiac chamber size and morphology was assessed using cardiac magnetic resonance imaging (cMRI). RV stroke work index, pulmonary artery (PA) compliance, PA elastance, PA pulsatility index, and right atrial pressure (RAP) were calculated at rest and maximal exercise. Ten patients (24%) had normal LV filling pattern, 20 patients (49%) had grade 1, and 11 patients (27%) had grade 2 diastolic dysfunction. Compared to patients with normal diastolic filling pattern, patients with diastolic dysfunction had lower RV end-diastolic volume (66 ± 11 ml/m2 vs. 79 ± 15 ml/m2, p = 0.02) and end-systolic volume (25 ± 7 ml/m2 vs. 32 ± 9 ml/m2, p = 0.04). An increase in mean RAP to ≥15 mmHg following exercise was not seen in patients with normal LV filling, compared to 4 patients (20...Continue Reading

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Nov 29, 2016·Circulation. Cardiovascular Imaging·Nicolaj Lyhne ChristensenJacob Eifer Møller

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Citations

Aug 22, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Karim KadryNikos Stergiopulos

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Methods Mentioned

BETA
RAP

Clinical Trials Mentioned

NCT02395107

Software Mentioned

STATA
Intellispace
SE
Philips

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