Association between leptin and IL-6 concentrations with cardiovascular risk in patients with rheumatoid arthritis

Clinical Rheumatology
José Antonio De Jesús Batún-GarridoIsela Esther Juárez-Rojop

Abstract

Pro-inflammatory cytokines such as leptin and IL-6 play an important role in the development of cardiovascular risk. Determine the relationship between leptin and IL-6 concentrations with cardiovascular risk in patients with rheumatoid arthritis. We determined IL-6 and leptin levels in 77 patients with the diagnosis of rheumatoid arthritis. The cardiovascular risk was calculated using the modified Framingham scale. Statistical analysis was performed using SPSS 22 considering a significant p < 0.05. Serum leptin concentrations and cardiovascular risk (CVR) factors were compared and found that there was a significant difference between higher leptin values and disease activity (p 0.047), obesity (p 0.038), positive rheumatoid factor (p 0.009), tobacco (p 0.009), and metabolic syndrome (p 0.001). Likewise, a significant relationship was found between lower leptin concentrations and hydroxychloroquine consumption (p = 0.023). We found significant difference between IL-6 concentrations and disease activity (p 0.028), hypertriglyceridemia (p 0.023), LDL-C (p 0.029), and smoking (0.005). Similarly, an association between hydroxychloroquine consumption and low concentrations of IL-6 was found (p 0.005). Framingham CVR was calculated an...Continue Reading

References

Dec 3, 1999·Journal of Internal Medicine·S SöderbergT Olsson
Jun 12, 2004·American Journal of Physiology. Endocrinology and Metabolism·Gina B Di GregorioPhilip A Kern
Jun 19, 2004·Current Opinion in Nephrology and Hypertension·Marcelo Lima de Gusmao Correia, William Geoffrey Haynes
Jul 15, 2009·Rheumatology International·Bozena Targońska-StepniakMaria Majdan
May 1, 2008·Current Immunology Reviews·Noriko IikuniAntonio La Cava
Sep 28, 2010·Lancet·David L ScottTom W J Huizinga
Apr 2, 2013·Autoimmunity Reviews·Ivana HollanMary C Wasko
May 8, 2014·Clinical and Experimental Immunology·G TianD Zhou
Apr 1, 2015·Nature Reviews. Rheumatology·Sarah Skeoch, Ian N Bruce

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Citations

Mar 31, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yiyun YuHejian Zou
Aug 25, 2019·International Journal of Molecular Sciences·Mar CarriónElena Neumann
Sep 28, 2018·Clinical Reviews in Allergy & Immunology·Federico CarboneMaurizio Cutolo
May 18, 2020·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Priyanka Pahan, Kalipada Pahan
Nov 17, 2020·Genome Génome / Conseil National De Recherches Canada·Wenxia LuoTed M Lakowski
Jan 28, 2021·Cells·Elena NeumannUlf Müller-Ladner
Nov 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Immacolata FaraoneLuigi Milella
Mar 9, 2021·Journal of Inflammation Research·Nandeeta SamadMainul Haque
Jul 27, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Gashaw DessieMeseret Derbew Molla

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