Association between leukocyte telomere length and serum carotenoid in US adults

European Journal of Nutrition
Kyoung-Bok Min, Jin-Young Min

Abstract

Telomere length is a biomarker for aging. It is known that oxidative stress can accelerate telomere shortening, whereas antioxidants can delay their shortening. Carotenoids as antioxidants are favorably associated with health- and aging-related diseases caused by oxidative stress, but their association with telomere length is less certain. We investigated the association between blood carotenoid levels and leukocyte telomere length in a representative sample of US adults. We analyzed 3660 participants aged 20 years and older in the 1999-2002 National Health and Nutrition Examination Survey. The levels of carotenoids-alpha-carotene, beta-carotene (trans + cis), beta-cryptoxanthin, combined lutein/zeaxanthin, and trans-lycopene-were measured using high-performance liquid chromatography. The leukocyte telomere length (T/S ratio) was assayed using the quantitative polymerase chain reaction method. A doubling of blood alpha-carotene, beta-carotene (trans + cis), and beta-cryptoxanthin was associated with approximately 2 % longer telomeres. Compared with the lowest carotenoid quartile of alpha-carotene, beta-carotene (trans + cis), and beta-cryptoxanthin, telomere length for adults with the highest quartiles was significantly increas...Continue Reading

References

Apr 18, 1991·Nature·E H Blackburn
Aug 15, 1997·The Journal of Biological Chemistry·B S Berlett, E R Stadtman
May 22, 2001·Archives of Biochemistry and Biophysics·A J Young, G M Lowe
May 10, 2002·Nucleic Acids Research·Richard M Cawthon
Jul 13, 2002·Trends in Biochemical Sciences·Thomas von Zglinicki
Jun 25, 2003·Toxicology·Maria L Urso, Priscilla M Clarkson
Oct 31, 2003·Molecular Aspects of Medicine·Wilhelm Stahl, Helmut Sies
Jun 14, 2005·Biochimica Et Biophysica Acta·Wilhelm Stahl, Helmut Sies
Sep 27, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·E MarianiP Mecocci
Nov 29, 2005·Molecular Aspects of Medicine·Norman I Krinsky, Elizabeth J Johnson
May 17, 2006·Trends in Ecology & Evolution·Pat Monaghan, Mark F Haussmann
Apr 9, 2008·Physiological Reviews·Geraldine Aubert, Peter M Lansdorp
Aug 13, 2008·Proceedings of the National Academy of Sciences of the United States of America·Hong JiangK Lenhard Rudolph
Mar 13, 2009·The American Journal of Clinical Nutrition·Qun XuHonglei Chen
Oct 27, 2009·Current Atherosclerosis Reports·Graziano Riccioni
Nov 26, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Masood A Shammas
Aug 23, 2011·Mutagenesis·Francesca MarconDomenico Palli
Apr 3, 2012·Mutation Research·Amaya Azqueta, Andrew R Collins
Sep 27, 2012·Brain, Behavior, and Immunity·Janice K Kiecolt-GlaserElizabeth Blackburn
Oct 18, 2012·European Journal of Clinical Nutrition·A-M K TiainenJ G Eriksson
Mar 13, 2013·Nature Reviews. Cardiology·Frej FyhrquistTimo Strandberg
Nov 20, 2013·Dementia and Geriatric Cognitive Disorders·Jin-young Min, Kyoung-bok Min
Aug 19, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Sonia García-CalzónUNKNOWN GENOI members
Dec 4, 2014·BMJ : British Medical Journal·Marta Crous-BouImmaculata De Vivo

❮ Previous
Next ❯

Citations

Apr 23, 2017·Mechanisms of Ageing and Development·Kedar N PrasadStephen C Bondy
Aug 28, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Tania-Marisa Freitas-SimoesAleix Sala-Vila
Jan 17, 2019·European Journal of Nutrition·Virginia BoccardiPatrizia Mecocci
May 31, 2018·Current Opinion in Clinical Nutrition and Metabolic Care·Anastasia Z KaleaJessica L Buxton
May 6, 2019·The American Journal of Clinical Nutrition·Silvia CanudasMònica Bulló
Jul 9, 2020·Marine Drugs·Vincenzo SorrentiDonald C Willcox
Jul 22, 2018·Lipids in Health and Disease·Mohsen MazidiMaciej Banach
Jun 21, 2020·Antioxidants·Ekaterina ProshkinaAlexey Moskalev
Nov 16, 2019·Advances in Nutrition·Marta Crous-BouAleix Sala-Vila
Dec 22, 2019·International Journal of Molecular Sciences·Wen LiGuowei Huang
Jun 13, 2018·Marine Drugs·Javier Torregrosa-CrespoRosa María Martínez-Espinosa
Jan 21, 2021·The American Journal of Clinical Nutrition·Benedetta Bartali, Richard D Semba
Jan 5, 2021·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Yuki MizunoHideki Imai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved