Association between LKB1 expression and prognosis of patients with solid tumours: an updated systematic review and meta-analysis

BMJ Open
Yun Hong RenXue Mei You

Abstract

Liver kinase B1 (LKB1) is considered a tumour suppressor that can control cell growth and metabolism. Whether LKB1 expression levels are related to clinicopathology and prognosis is controversial. This review aimed to quantitatively examine the latest evidence on this question. An updated systematic review and meta-analysis on the association between LKB1 expression and prognosis of patients with solid tumours were performed. Eligible studies were identified through literature searches from database establishment until 15 June 2018 in the following databases: Embase, PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure and Wan Fang databases. The association between LKB1 expression and clinicopathological characteristics, overall survival (OS), disease-free survival (DFS) and relapse-free survival (RFS) of patients with solid tumours were reported. Sufficient data were available to calculate the OR or HR and 95% CI. Relevant data were meta-analysed for OS, DFS, RFS and various clinical parameters. The systematic review included 25 studies containing 6012 patients with solid tumours. Compared with patients with high LKB1 expression, patients with low expression showed significantly shorter OS in univ...Continue Reading

Citations

Feb 13, 2021·Diagnostics·Baharia MograbiPaul Hofman
Nov 20, 2021·Medicine·Chunxuan LinTaisheng Liu

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