Association between locomotor response to novelty and light reinforcement: sensory reinforcement as a rodent model of sensation seeking.

Behavioural Brain Research
Amy M GancarzJerry B Richards

Abstract

The human personality trait of sensation seeking (SS) indicates an attraction to novel sensations and experiences, and is associated with greater likelihood of drug abuse. In rodents, locomotor activity in a novel environment (Loco) has been found to predict drug self-administration (SA), and has been hypothesized to be a translational model of human SS. Previously, we reported (Gancarz et al., 2011) that high responder (HR) animals responded more than low responder (LR) animals to produce a response contingent light onset. The primary goal of this paper was a detailed analysis of the association between Loco and light contingent responding in a large sample of rats (n = 93). Male rats were pre-exposed to dark operant test chambers for ten 30 min sessions and baseline levels of responding (snout poking) were determined. The pre-exposure phase was followed by 6 sessions during which active responding produced a visual sensory reinforcer (VSR; 5 s light onset) according to a variable interval 1 min schedule of reinforcement. After completion of the VSR phase, Loco was tested. The activating effects (total responding) of light were associated with Loco, but the response guiding effects (proportion of active responding) of the ligh...Continue Reading

References

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Citations

Nov 13, 2012·Psychopharmacology·Amy M GancarzJerry B Richards
Apr 9, 2014·Experimental and Clinical Psychopharmacology·David R LloydJerry B Richards
Jul 21, 2012·Behavioural Brain Research·David R LloydJerry B Richards
Aug 8, 2012·Behavioural Processes·David R LloydJerry B Richards
Apr 25, 2015·Behavioural Brain Research·Agnes Norbury, Masud Husain
Apr 8, 2017·Genes, Brain, and Behavior·C P KingP J Meyer
Jun 3, 2017·Neuroscience and Biobehavioral Reviews·Gabor EgervariYasmin L Hurd
May 29, 2013·Genes, Brain, and Behavior·J B RichardsA A Palmer
Feb 23, 2020·Frontiers in Behavioral Neuroscience·Valentina CastelliFulvio Plescia

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