Association between long-term exposure to ambient air pollution and diabetes mortality in the US

Environmental Research
Chris C LimGeorge D Thurston

Abstract

Recent mechanistic and epidemiological evidence implicates air pollution as a potential risk factor for diabetes; however, mortality risks have not been evaluated in a large US cohort assessing exposures to multiple pollutants with detailed consideration of personal risk factors for diabetes. We assessed the effects of long-term ambient air pollution exposures on diabetes mortality in the NIH-AARP Diet and Health Study, a cohort of approximately a half million subjects across the contiguous U.S. The cohort, with a follow-up period between 1995 and 2011, was linked to residential census tract estimates for annual mean concentration levels of PM2.5, NO2, and O3. Associations between the air pollutants and the risk of diabetes mortality (N = 3598) were evaluated using multivariate Cox proportional hazards models adjusted for both individual-level and census-level contextual covariates. Diabetes mortality was significantly associated with increasing levels of both PM2.5 (HR = 1.19; 95% CI: 1.03-1.39 per 10 μg/m3) and NO2 (HR = 1.09; 95% CI: 1.01-1.18 per 10 ppb). The strength of the relationship was robust to alternate exposure assessments and model specifications. We also observed significant effect modification, with elevated mor...Continue Reading

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Citations

Jan 5, 2019·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Samir Helmy Assaad KhalilAlexey V Zilov
May 16, 2019·Current Environmental Health Reports·Georgia PapadogeorgouAntonella Zanobetti
Nov 30, 2018·International Journal of Molecular Sciences·Luis Alberto Anguiano-SevillaMaría Eugenia Jaramillo-Flores
Apr 7, 2019·Scientific Reports·Frans E GrevenBert Brunekreef
Jul 3, 2020·Environmental Science and Pollution Research International·Ping GuoJianhui Li
Apr 25, 2020·Sensors·Florentin Michel Jacques BulotSimon James Cox
Jul 22, 2019·Current Diabetes Reports·Chris C Lim, George D Thurston
Jan 7, 2020·Therapeutic Advances in Endocrinology and Metabolism·Yongze LiCheng Han
Oct 18, 2020·Environmental Research·Kanawat PaoinUNKNOWN Thai Cohort Study Team Australia
Dec 24, 2018·Environmental Research·Mohsen Ansari, Mohammad Hassan Ehrampoush

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