Association between Low Estimated Glomerular Filtration Rate and Risk of Cerebral Small-Vessel Diseases: A Meta-Analysis

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Yuanyuan LiuYining Huang

Abstract

Although chronic kidney disease has been linked to cerebral small-vessel disease (CSVD), a definite relationship between them has not been established. This study assessed whether low estimated glomerular filtration is associated with risk of different subtypes of CSVDs. Electronic databases were systematically searched for studies reporting an odds ratio of the association between low estimated glomerular filtration and CSVD risk. Sixteen studies, including 10,534 participants, were identified. A fix effects model was applied and odds ratios (ORs) with 95% confidence intervals were presented. Overall, risk of CSVDs was greater in individuals with low estimated glomerular filtration (OR = 2.20). Stratified analyses consistently showed significant associations across different subtypes, with pooled OR being greatest in subjects with silent cerebral infarction (SCI) (OR = 2.71) and cerebral microbleed (OR = 2.70). A pooled estimate of studies showing OR as a continuous variable showed results consistent with the former analysis (OR = .98 per standard deviation decrease) in low estimated glomerular filtration. This study revealed that low estimated glomerular filtration was significantly associated with risk of CSVDs. Low estimate...Continue Reading

References

Sep 1, 1994·The Journal of Pediatrics·A R HohnJ H Dwyer
May 10, 2005·Stroke; a Journal of Cerebral Circulation·Clinton B WrightCharles DeCarli
Jul 4, 2007·Circulation·Ernesto L SchiffrinJohannes F E Mann
Oct 27, 2007·Stroke; a Journal of Cerebral Circulation·Michiel J BosMonique M B Breteler
Dec 1, 2007·Stroke; a Journal of Cerebral Circulation·M Arfan IkramMonique M B Breteler
Mar 8, 2008·Stroke; a Journal of Cerebral Circulation·Koshi NakamuraUNKNOWN Asia Pacific Cohort Studies Collaboration
Dec 17, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Toshiharu NinomiyaRachel Huxley
Mar 31, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jean-Marc BugnicourtZiad A Massy
Apr 15, 2009·Cerebrovascular Diseases·J RoquerJ Castillo
Jun 12, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·R BouchiY Iwamoto
Sep 14, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Wakoh TakahashiShigeharu Takagi
Oct 5, 2010·BMJ : British Medical Journal·Meng LeeBruce Ovbiagele
Jun 29, 2012·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takashi ShimoyamaSoichiro Mochio
Apr 23, 2013·Lancet Neurology·Joanna M WardlawMartin Dichgans
Jul 13, 2013·Stroke; a Journal of Cerebral Circulation·Bruce OvbiageleChelsea S Kidwell
Jan 1, 2013·Kidney International Supplements
Jul 22, 2014·Journal of Clinical Neurology·Tae-Jin SongJi Hoe Heo
Dec 31, 2014·Cerebrovascular Diseases·Stephen D J MakinJoanna M Wardlaw

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Citations

Jul 4, 2018·The Journal of International Medical Research·Nobuo KajitaniJun Wada
Mar 1, 2019·Medicine and Science in Sports and Exercise·Ulf G BronasMelissa Lamar
Sep 13, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Dearbhla Kelly, Peter Malcolm Rothwell
Aug 20, 2020·Stroke; a Journal of Cerebral Circulation·Dearbhla M KellyUNKNOWN Oxford Vascular Study
May 1, 2016·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·Kazuhiko Tsuruya
Oct 18, 2020·Toxics·Soisungwan SatarugKenneth R Phelps
Jun 4, 2021·Stroke; a Journal of Cerebral Circulation·Dearbhla M KellyManish M Sood

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