Association between lung cancer somatic mutations and occupational exposure in never-smokers

The European Respiratory Journal
Christophe Paristo the BioCAST/IFCT- 1002 study

Abstract

Occupational exposure constitutes a common risk factor for lung cancer. We observed molecular alterations in 73% of never-smokers, 35% of men and 8% of women were exposed to at least one occupational carcinogen. We report herein associations between molecular patterns and occupational exposure.BioCAST was a cohort study of lung cancer in never-smokers that reported risk factor exposure and molecular patterns. Occupational exposure was assessed via a validated 71-item questionnaire. Patients were categorised into groups that were unexposed and exposed to polycyclic aromatic hydrocarbons (PAH), asbestos, silica, diesel exhaust fumes (DEF), chrome and paints. Test results were recorded for EGFR, KRAS, HER2, BRAF and PIK3 mutations, and ALK alterations.Overall, 313 out of 384 patients included in BioCAST were analysed. Asbestos-exposed patients displayed a significantly lower rate of EGFR mutations (20% versus 44%, p=0.033), and a higher rate of HER2 mutations (18% versus 4%, p=0.084). ALK alterations were not associated with any occupational carcinogens. The DEF-exposed patients were diagnosed with a BRAF mutation in 25% of all cases. Chrome-exposed patients exhibited enhanced HER2 and PIK3 mutation frequency.Given its minimal eff...Continue Reading

References

Jan 7, 1999·International Journal of Occupational and Environmental Health·W Ahrens, F Merletti
Apr 1, 1999·American Journal of Respiratory Cell and Molecular Biology·K Husgafvel-PursiainenH Vainio
Nov 27, 2002·The European Respiratory Journal·C ParisM Letourneux
Sep 21, 2007·Nature Reviews. Cancer·Sophie SunAdi F Gazdar
Sep 1, 2009·The European Respiratory Journal·A ScherpereelUNKNOWN European Respiratory Society/European Society of Thoracic Surgeons Task Force
Apr 3, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sébastien CouraudPierre-Jean Souquet
Jul 11, 2012·Nature Reviews. Clinical Oncology·Frédérique NowakFabien Calvo
Sep 17, 2013·Revue des maladies respiratoires·S CouraudUNKNOWN les membres du Groupe de travail « non-fumeurs de l’IFCT »
Dec 18, 2013·Cancer Letters·María Torres-DuránAlberto Ruano-Ravina
May 16, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Satu Mäki-NevalaSakari Knuutila
Jul 19, 2014·The European Respiratory Journal·María Torres-DuránJuan Miguel Barros-Dios
Feb 7, 2015·The European Respiratory Journal·Sébastien CouraudUNKNOWN French Cooperative Intergroup IFCT
Mar 5, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Lynette M ShollUNKNOWN LCMC Investigators
Mar 7, 2015·The European Respiratory Journal·Sébastien CouraudUNKNOWN BioCAST/IFCT-1002 study investigators
May 11, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tomoya KawaguchiAkihide Matsumura
Aug 28, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Satu Mäki-NevalaSakari Knuutila
Sep 7, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Cécilia Gibelin, Sébastien Couraud
Nov 2, 2016·The European Respiratory Journal·Alberto Ruano-RavinaJuan Miguel Barros-Dios
Feb 13, 2017·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Nicolas GuibertJulien Mazières

❮ Previous
Next ❯

Citations

Mar 10, 2018·The European Respiratory Journal·Marie UguenArnaud Uguen
Mar 28, 2019·Tuberculosis and Respiratory Diseases·Chan Kwon Park, Seung Joon Kim

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.