Association Between Magnetic Resonance Imaging-Proton Density Fat Fraction and Liver Histology Features in Patients With Nonalcoholic Fatty Liver Disease or Nonalcoholic Steatohepatitis

Gastroenterology
Benjamin Wildman-TobrinerMustafa R Bashir

Abstract

Patients with nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH) often require histologic assessment via liver biopsy. Magnetic resonance imaging (MRI)-based methods for measuring liver triglycerides based on proton density fat fraction (PDFF) are increasingly used as a noninvasive tool to identify patients with hepatic steatosis and to assess for change in liver fat over time. We aimed to determine whether MRI-PDFF accurately reflects a variety of liver histology features in patients with NAFLD or NASH. We performed a retrospective analysis of pooled data from 3 phase 2a trials of pharmacotherapies for NAFLD or NASH. We collected baseline clinical, laboratory, and histopathology data on all subjects who had undergone MRI analysis in 1 of the trials. We assessed the relationship between liver PDFF values and liver histologic findings using correlation and area under the receiver operating characteristic (AUROC) analyses. As an ancillary analysis, we also simulated a clinical trial selection process and calculated subject exclusion rates and differences in population characteristics caused by PDFF inclusion thresholds of 6% to 15%. In 370 subjects, the mean baseline PDFF was 17.4% ± 8.6%. Baseline PD...Continue Reading

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Citations

Apr 26, 2019·Nutrients·Yixin JiangJohanna Nattenmüller
Jul 18, 2019·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiroyuki IgarashiNaoki Kumashiro
Mar 11, 2020·Nature Reviews. Gastroenterology & Hepatology·Judith Aron-WisnewskyKarine Clément
Jul 4, 2020·Endocrinology and Metabolism·Dae Ho Lee
Nov 21, 2020·European Journal of Gastroenterology & Hepatology·Anna RoskillyIan A Rowe
Oct 5, 2020·Magnetic Resonance Imaging·Edward M LawrenceScott B Reeder
Jan 14, 2021·Journal of Magnetic Resonance Imaging : JMRI·Jelte J SchaapmanHildo J Lamb
Oct 27, 2020·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Masahiro OgawaShuji Terai
Nov 17, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gen ChenZhen Li
Jan 31, 2021·Scientific Reports·Lokesh BasavarajappaKenneth Hoyt
Aug 4, 2021·Endocrinología, Diabetes Y Nutrición·Diego MenesesAna Isabel de-Cos-Blanco
Nov 24, 2021·Experimental and Clinical Transplantation : Official Journal of the Middle East Society for Organ Transplantation·Jacob D de BoerE L I A C Advisory Committee
Oct 10, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Anneli AnderssonStephen Harrison

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