Association Between Major Depressive Disorder and Sleep Disturbances Through Inflammation in Adolescents

Frontiers in Psychiatry
Abhishek ReddyLi Li

Abstract

Although approximately 13% of adolescents suffer from Major Depressive Disorder (MDD), and many adolescents have reported sleep disturbances, the relationship between sleep disturbances and MDD in adolescents is poorly understood. Thus, our objective was to study how adolescent MDD was related to sleep disturbances in a cross-sectional study, and the potential role of inflammation linking adolescent MDD to sleep disturbances. Ninety-two female and male, African American and White, adolescents aged 15 to 18 years completed the study. Adolescents were diagnosed with MDD according to the Diagnostic and Statistical Manual of Mental Disorders-5 as confirmed by the MINI International Diagnostic Interview. The severity of depression was assessed using the Quick Inventory of Depressive Symptomatology. Sleep disturbance was measured using the Pediatric Sleep Questionnaires (PSQ). Blood sample was collected from each participant for measuring the inflammatory factors. Compared with the controls (n=39), adolescents with MDD (n=53) had greater PSQ scores (0.32 ± 0.02 vs. 0.10 ± 0.02). In adolescents with MDD, PSQ scores were correlated with the severity of depressive symptoms (r=0.31, p<0.05). In addition, tumor necrosis factor-α levels we...Continue Reading

References

May 10, 2002·Annals of the New York Academy of Sciences·J M KruegerP Taishi
May 26, 2004·Brain, Behavior, and Immunity·Monika HaackJanet M Mullington
Oct 3, 2007·Archives of General Psychiatry·John S MarchJoanne Severe
Nov 10, 2007·Journal of Pediatric Psychology·Daniel B ChorneyBrett R Kuhn
Jan 31, 2008·Journal of Consulting and Clinical Psychology·Tina R GoldsteinDavid A Brent
Dec 17, 2008·Current Pharmaceutical Design·James M Krueger
Dec 18, 2009·Biological Psychiatry·Yekta DowlatiKrista L Lanctôt
Mar 25, 2010·The Journal of Clinical Psychiatry·David V SheehanBerney Wilkinson
Aug 5, 2010·International Journal of Methods in Psychiatric Research·Ira H BernsteinGraham J Emslie
Feb 9, 2011·Journal of Affective Disorders·Chiara BaglioniDieter Riemann
Nov 11, 2011·Pflügers Archiv : European journal of physiology·Luciana BesedovskyJan Born
Nov 25, 2011·Psychology Research and Behavior Management·Sarah E HetrickSally N Merry
Jan 31, 2012·Asian Journal of Psychiatry·Uma Rao
Apr 25, 2013·Journal of Sleep Research·Mari HysingBørge Sivertsen
Sep 13, 2013·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Natalie T MillsBernhard T Baune
Aug 27, 2014·Pediatrics·Judith OwensUNKNOWN Committee on Adolescence
May 15, 2015·Journal of Child and Family Studies·Cheryl HolmesPaula Neese
Apr 14, 2017·Advances in Experimental Medicine and Biology·Paulina MiłkowskaTomasz Wolańczyk
Jul 4, 2017·Frontiers in Psychiatry·Badari BirurLi Li
Nov 21, 2017·Sleep Medicine Reviews·Matthew D RockstromJames M Krueger
Apr 5, 2018·Sleep·Sara NowakowskiRebecca C Thurston
Jun 8, 2018·Depression and Anxiety·Dylan JohnsonIan Colman
Oct 30, 2018·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·Debora Lee OhNadine Burke Harris

❮ Previous
Next ❯

Methods Mentioned

BETA
blood draw

Software Mentioned

MPSQ Discovery Workbench
SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.