Association between major depressive symptoms in heart failure and impaired regional cerebral blood flow in the medial temporal region: a study using 99m Tc-HMPAO single photon emission computerized tomography (SPECT)

Psychological Medicine
T C T F AlvesG F Busatto

Abstract

Depressive symptoms are frequently associated with heart failure (HF), but the brain mechanisms underlying such association are unclear. We hypothesized that the presence of major depressive disorder (MDD) emerging after the onset of HF would be associated with regional cerebral blood flow (rCBF) abnormalities in medial temporal regions previously implicated in primary MDD, namely the hippocampus and parahippocampal gyrus. Using 99mTc-SPECT, we measured rCBF in 17 elderly MDD-HF patients, 17 non-depressed HF patients, and 18 healthy controls, matched for demographic variables. Group differences were investigated with Statistical Parametric Mapping. Significant rCBF reductions in MDD-HF patients relative to both non-depressed HF patients and healthy controls were detected in the left anterior parahippocampal gyrus and hippocampus (ANOVA, p=0.008 corrected for multiple comparisons) and the right posterior hippocampus and parahippocampal gyrus (p=0.005 corrected). In the overall HF group, there was a negative correlation between the severity of depressive symptoms and rCBF in the right posterior hippocampal/parahippocampal region (p=0.045 corrected). These findings are consistent with the notion that the medial temporal region is ...Continue Reading

Citations

Dec 12, 2007·Heart Failure Reviews·Christine E Skotzko
Aug 25, 2010·Current Opinion in Psychiatry·Tânia C de Toledo Ferraz AlvesGeraldo F Busatto
Sep 2, 2006·Neurological Research·Tânia Corrêa de Toledo Ferraz Alves, Geraldo F Busatto
Jul 9, 2014·Current Heart Failure Reports·Jennifer A OgrenMary A Woo
Nov 27, 2010·Heart Failure Clinics·Willem J KopStephen S Gottlieb
Nov 1, 2006·Neuroscience·A M Soza Ried, M Aviles
Jul 12, 2016·Circulation Journal : Official Journal of the Japanese Circulation Society·Tetsu Watanabe
Sep 17, 2020·Future Cardiology·Mark DayerStuart D Rosen
Mar 11, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Erdi BabayiğitYüksel Çavuşoğlu

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