Association Between Maternal 2nd Trimester Plasma Folate Levels and Infant Bronchiolitis

Maternal and Child Health Journal
S VereenKecia N Carroll

Abstract

Objectives Viral bronchiolitis is the most common cause of infant hospitalization. Folic acid supplementation is important during the periconceptional period to prevent neural tube defects. An area of investigation is whether higher prenatal folate is a risk factor for childhood respiratory illnesses. We investigated the association between maternal 2nd trimester plasma folate levels and infant bronchiolitis. Methods We conducted a retrospective cohort analysis in a subset of mother-infant dyads (n = 676) enrolled in the Conditions Affecting Neurocognitive Development and Learning in Early Childhood study and Tennessee Medicaid. Maternal folate status was determined using 2nd trimester (16-28 weeks) plasma samples. Bronchiolitis diagnosis in the first year of life was ascertained using International Classification of Diagnosis-9 codes from Medicaid administrative data. We used multivariable logistic regression to assess the adjusted association of prenatal folate levels and infant bronchiolitis outcome. Results Half of the women in this lower-income and predominately African-American (84%) study population had high levels of folate (median 2nd trimester level 19.2 ng/mL) and 21% of infants had at least one bronchiolitis healthc...Continue Reading

References

Dec 24, 1992·The New England Journal of Medicine·A E Czeizel, I Dudás
Mar 10, 2001·The American Journal of Medicine·M A Ross, R J Zalenski
Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gregory P WhitePatrick G Holt
Nov 24, 2006·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Gregory P WhitePatrick G Holt
Aug 28, 2007·Current Opinion in Immunology·Ian M AdcockKazuhiro Ito
Dec 5, 2008·Archives of Disease in Childhood·S E HåbergW Nystad
Apr 14, 2009·The Journal of Allergy and Clinical Immunology·Kecia N CarrollTina V Hartert
Aug 5, 2009·Current Opinion in Allergy and Clinical Immunology·Susan L Prescott, Vicki Clifton
Nov 3, 2009·American Journal of Epidemiology·Melissa J WhitrowMichael J Davies
Nov 26, 2010·The Journal of Allergy and Clinical Immunology·Siri E HåbergWenche Nystad
Oct 11, 2011·American Journal of Obstetrics and Gynecology·Marit P MartinussenMichael B Bracken
Oct 29, 2011·The European Respiratory Journal·Marga B M BekkersAlet H Wijga
Feb 1, 2013·The Journal of Nutrition·Amy M BranumBarbara J Singer
Mar 9, 2013·The European Respiratory Journal·Elisabeth T M LeermakersLiesbeth Duijts
Dec 24, 2013·The Journal of Allergy and Clinical Immunology·Sunita Sharma, Augusto Litonjua
Mar 29, 2014·American Journal of Epidemiology·Sreenivas P VeerankiKecia N Carroll
Nov 24, 2017·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·A RoyK N Carroll

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Citations

Jun 18, 2019·Paediatric and Perinatal Epidemiology·Margaret A AdgentKecia N Carroll
Dec 5, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Chihiro MiyashitaReiko Kishi

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