Association between metabolic syndrome and chronic kidney disease in a Chinese urban population

Clinica Chimica Acta; International Journal of Clinical Chemistry
Juan ChenDongmei Xu

Abstract

Few studies have examined the relationships between the prevalence of chronic kidney disease (CKD) and the metabolic risk factors in a developing country such as China, where genetic and environmental backgrounds differ from those in Western countries. The subjects of this cross-sectional study were the individuals from 18 to 92y. The metabolic syndrome (MetS) was defined based on the criteria of Adult Treatment Panel Third Report (ATP III), but using body mass index (BMI) instead of waist circumference. CKD was defined as decreased estimated glomerular filtration rate (eGFR<60mL/min/1.73m2) or presence of proteinuria (urine protein≥1+) assessed using dipstick method. A total of 26,601 subjects (average age of 48.7y) were analyzed. Among them, the prevalence of the MetS and CKD was 36.4% and 3.0%, respectively. After adjustment for age, gender, cigarette smoking and alcohol drinking, the prevalence of CKD was significantly greater in subjects with than without MetS (OR 1.99, 95% CI 1.57-2.53, p<0.001). Multivariate-adjusted odd ratios for CKD in subjects with 3, 4 or 5 MetS components were 1.82 (95% CI 1.31-2.52, p<0.001), 2.92 (95% CI 2.09-4.09, p<0.001), and 3.07 (95% CI 1.67-5.67, p<0.001), respectively. After further adjust...Continue Reading

References

Jan 15, 2010·JAMA : the Journal of the American Medical Association·Katherine M FlegalLester R Curtin

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Citations

Jan 25, 2018·Diseases·Vaia D Raikou, Sotiris Gavriil
Oct 24, 2019·International Urology and Nephrology·Ryuichi KawamotoAsuka Kikuchi
Aug 25, 2020·Methods of Information in Medicine·Tianshu ZhouZhong Liu
Aug 3, 2019·International Journal of Endocrinology and Metabolism·Marzieh BakhshayeshkaramKamran B Lankarani
Aug 14, 2020·Biological Trace Element Research·Cristhian Neftaly Sánchez-SolísSamuel Treviño
Jan 29, 2021·Scientific Reports·Yu-Ji LeeSung Rok Kim
Aug 26, 2021·Metabolic Syndrome and Related Disorders·Rachida MoustakimRekia Belahsen

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