Association between metabolic syndrome, BMI, and serum vitamin D concentrations in rheumatoid arthritis.

Clinical Rheumatology
Ladan GoshayeshiLena Goshayeshi

Abstract

Rheumatoid arthritis (RA) is the most common autoimmune arthritis. The impact of chronic inflammation on atherosclerosis and insulin resistance has been observed in several autoimmune diseases. On the other hand, metabolic syndrome (MetS); a cluster of traditional risk factors for atherosclerosis and diabetes seems to be prevalent in RA patients. It is reasonable to think that protective factors against inflammation can protect patients against atherosclerosis and diabetes, too. Vitamin D (Vit D), a novel immunomodulator, is recently considered to play a protective role against cardiovascular diseases, insulin resistance, and obesity. This cross-sectional study was designed to evaluate the impact of serum Vit D on MetS and body mass index (BMI). One hundred twenty RA patients were enrolled. MetS was assessed according to Adult Treatment Panel III criteria. All patients with known confounders influencing Vit D serum levels were excluded. Serum value of 25-hydroxyvitamin D (25(OH)D) was measured using a commercial ELISA kit. Data were analyzed by SPSS software. A logistic regression analysis stated that prednisolone dosage [p = 0.028, β = 0.177, odds ratio (OR) = 1.194, confidence interval (CI, 1.09-1.32)], age [p = 0.002, β = 0....Continue Reading

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Citations

Jun 19, 2013·International Journal of Rheumatic Diseases·Debashish Danda
Feb 23, 2013·Mediators of Inflammation·Iván Ferraz-AmaroMiguel A González-Gay
Apr 11, 2014·Clinical Rheumatology·Young-Eun ParkGeun-Tae Kim
Jul 3, 2013·The Journal of Rheumatology·Prabha RanganathanMariana J Kaplan
Jun 2, 2018·The Open Rheumatology Journal·Sahebari MaryamRavanshad Yalda
Feb 23, 2020·Frontiers in Physiology·Mahmoud Mustafa Ali AbulmeatyAsmaa M Malash
Oct 29, 2019·Nutrición hospitalaria·Héctor Vázquez-LorenteElena Planells

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