Abstract
This study aimed to determine the role of mitofusin 2 (MFN2) gene polymorphisms in the risk and prognosis of acute liver failure (ALF). A total of 298 blood samples were collected from 138 ALF patients (case group) and 160 healthy participants (control group). Coagulation function, glutamic pyruvic transaminase (GPT), glutamic oxaloacetic transaminase (GOT), total bilirubin (TB), blood ammonia and lactic acid (LA) were measured. The predictive evaluation of MFN2 gene polymorphisms in the risk and prognosis of ALF patients was estimated using Kaplan-Meier survival analysis, haplotype analysis, binary logistic regression analysis and Cox regression analysis. Higher levels of GPT, GOT, TB, blood ammonia and LA were observed in ALF patients with the GG genotype of rs873457 or the TT genotype of rs4846085 than in those with the CC genotype of these two SNPs. The GTACAGC and GTGTGGC haplotypes were a protective factor and a risk factor for ALF, respectively. Blood ammonia and LA levels were independent risk factors and the CC genotype of rs873457 and the CC genotype of rs4846085 were protective factors for ALF. ALF patients with the GG genotype of rs873457 or the TT genotype of rs4846085 had a lower survival rate than those with othe...Continue Reading
References
Apr 12, 1997·Lancet·A Mas, J Rodés
Feb 28, 2002·Lancet·William BernalJulia Wendon
Feb 28, 2003·Pharmacogenomics·Hongyu ZhaoMitchell H Gail
Apr 21, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Julie PolsonUNKNOWN American Association for the Study of Liver Disease
May 3, 2008·Seminars in Liver Disease·William M Lee
Mar 10, 2009·Mitochondrion·Olga Martins de Brito, Luca Scorrano
Jul 20, 2010·Lancet·William BernalJulia Wendon
Sep 8, 2010·Metabolism: Clinical and Experimental·Yong ZhangWenpei Xiang
Oct 14, 2010·Journal of Atherosclerosis and Thrombosis·Zuoguang WangZhaosu Wu
Feb 18, 2011·Current Opinion in Critical Care·Jody C Olson, Patrick S Kamath
Apr 29, 2011·PloS One·Cord DrögemüllerTosso Leeb
Jul 1, 2011·Neurology·J M PolkeM M Reilly
Mar 20, 2012·Proceedings of the National Academy of Sciences of the United States of America·David SebastiánAntonio Zorzano
Mar 27, 2012·Reproductive Sciences·Yonghui GaoTing Zhang
Aug 2, 2012·Nature Reviews. Molecular Cell Biology·Rosario RizzutoCristina Mammucari
Aug 9, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hong-Min NiWen-Xing Ding
Apr 23, 2013·Placenta·W PangW Xiang
Jun 6, 2014·Journal of Cellular and Molecular Medicine·Jun LiYong Zhang
Jun 10, 2016·Cleveland Clinic Journal of Medicine·Tavankit SinghIbrahim A Hanouneh