Association between MFN2 gene polymorphisms and the risk and prognosis of acute liver failure: a case-control study in a Chinese population

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
Y-L WeiY Xu

Abstract

This study aimed to determine the role of mitofusin 2 (MFN2) gene polymorphisms in the risk and prognosis of acute liver failure (ALF). A total of 298 blood samples were collected from 138 ALF patients (case group) and 160 healthy participants (control group). Coagulation function, glutamic pyruvic transaminase (GPT), glutamic oxaloacetic transaminase (GOT), total bilirubin (TB), blood ammonia and lactic acid (LA) were measured. The predictive evaluation of MFN2 gene polymorphisms in the risk and prognosis of ALF patients was estimated using Kaplan-Meier survival analysis, haplotype analysis, binary logistic regression analysis and Cox regression analysis. Higher levels of GPT, GOT, TB, blood ammonia and LA were observed in ALF patients with the GG genotype of rs873457 or the TT genotype of rs4846085 than in those with the CC genotype of these two SNPs. The GTACAGC and GTGTGGC haplotypes were a protective factor and a risk factor for ALF, respectively. Blood ammonia and LA levels were independent risk factors and the CC genotype of rs873457 and the CC genotype of rs4846085 were protective factors for ALF. ALF patients with the GG genotype of rs873457 or the TT genotype of rs4846085 had a lower survival rate than those with othe...Continue Reading

References

Apr 12, 1997·Lancet·A Mas, J Rodés
Feb 28, 2003·Pharmacogenomics·Hongyu ZhaoMitchell H Gail
Apr 21, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Julie PolsonUNKNOWN American Association for the Study of Liver Disease
May 3, 2008·Seminars in Liver Disease·William M Lee
Jul 20, 2010·Lancet·William BernalJulia Wendon
Oct 14, 2010·Journal of Atherosclerosis and Thrombosis·Zuoguang WangZhaosu Wu
Feb 18, 2011·Current Opinion in Critical Care·Jody C Olson, Patrick S Kamath
Mar 20, 2012·Proceedings of the National Academy of Sciences of the United States of America·David SebastiánAntonio Zorzano
Aug 2, 2012·Nature Reviews. Molecular Cell Biology·Rosario RizzutoCristina Mammucari
Aug 9, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hong-Min NiWen-Xing Ding
Jun 6, 2014·Journal of Cellular and Molecular Medicine·Jun LiYong Zhang
Jun 10, 2016·Cleveland Clinic Journal of Medicine·Tavankit SinghIbrahim A Hanouneh

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Citations

Nov 6, 2020·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Congchen TangLichun Wang

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Methods Mentioned

BETA
GTPase
genotyping
PCR

Software Mentioned

SPSS
SHEsis

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