Association between monocyte chemoattractant protein-1 and blood pressure in smokers

The Journal of International Medical Research
Maki KomiyamaKoji Hasegawa

Abstract

Objective The expression level of monocyte chemoattractant protein-1 (MCP-1) is increased in atherosclerotic regions, inducing monocyte migration to the blood vessel wall. Although the serum MCP-1 concentration is higher in patients with than without cardiovascular disease, the precise correlations between the serum MCP-1 concentration and factors associated with smoking and atherosclerosis are unknown. Methods The serum MCP-1 concentration was measured using an enzyme-linked immunosorbent assay in 207 consecutive smokers who visited our smoking cessation clinic. Results Sex-adjusted analysis of smokers revealed that the MCP-1 concentration was positively correlated with age ( β = 0.311), smoking duration ( β = 0.342), systolic blood pressure ( β = 0.225), and diastolic blood pressure ( β = 0.137) but not with the body mass index. Multivariate regression analysis showed that smoking duration and systolic blood pressure were independent determinants of the MCP-1 concentration. Conclusions The MCP-1 concentration was positively correlated with blood pressure among smokers. Long-term smokers with high blood pressure may be more susceptible to plaque rupture at atherosclerotic lesion sites.

References

Sep 1, 1991·British Journal of Addiction·T F HeathertonK O Fagerström
Dec 1, 1965·Archives of General Psychiatry·W W ZungM J Short
Nov 24, 1999·Atherosclerosis·T J Reape, P H Groot
Feb 28, 2002·Cardiovascular Research·Stefan StörkPeter Angerer
Jan 1, 1965·Archives of General Psychiatry·W W ZUNG
Oct 3, 2003·Cancer Cell·Bo-qing ZhuJohn P Cooke
Mar 20, 2004·Expert Review of Cardiovascular Therapy·Shiro Kitamoto, Kensuke Egashira
Dec 21, 2006·Archives of Physiology and Biochemistry·Elena Dragomir, Maya Simionescu
Mar 6, 2007·Journal of Periodontology·Amjad AlmasriByron Olson
May 15, 2007·Current Opinion in Lipidology·Henrike Sell, Jürgen Eckel
May 25, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Blai CollJorge Joven
Sep 2, 2008·The International Journal of Biochemistry & Cell Biology·Esther MelgarejoJosé Luis Urdiales
May 16, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Satish L DeshmaneBassel E Sawaya
Jul 2, 2009·Clinical Science·Jianli Niu, Pappachan E Kolattukudy
Nov 21, 2009·Recent Patents on Cardiovascular Drug Discovery·Miina K Ohman, Daniel T Eitzman
Nov 13, 2010·Circulation Journal : Official Journal of the Japanese Circulation Society·Sayaka ShimadaYuko Takahashi
Jan 11, 2011·Biologie aujourd'hui·Lucie Poupel, Christophe Combadière
Apr 7, 2011·Expert Opinion on Investigational Drugs·Young Sun KangDae Ryong Cha
Jun 16, 2012·International Journal of Immunopathology and Pharmacology·A AntonelliE Ferrannini
Feb 6, 2013·Nature Reviews. Cardiology·Adam Csordas, David Bernhard
Oct 3, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Arsen ArakelyanAnna Boyajyan
Dec 25, 2013·Trends in Endocrinology and Metabolism : TEM·Mingyi WangEdward G Lakatta
May 28, 2014·Current Pharmaceutical Design·Juntang LinXinjie Lu
Jul 1, 2014·Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University·Helena MartynowiczGrzegorz Mazur
Nov 3, 2016·Journal of Atherosclerosis and Thrombosis·Maki KomiyamaKoji Hasegawa

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay

Software Mentioned

Statistical Package for the Social Sciences ( SPSS ) Statistics

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease
Kaur HarsimranSambyal Vasudha
Advances in Experimental Medicine and Biology
T Yoshimura, E J Leonard
Clinical Research in Cardiology : Official Journal of the German Cardiac Society
Katarzyna KorybalskaJanusz Witowski
© 2022 Meta ULC. All rights reserved