Abstract
TP53, the most frequently mutated gene in breast cancer, is more frequently altered in HER2-enriched and basal-like breast cancer. However, no studies have clarified the role of TP53 status as a prognostic and predictive marker of triple-negative breast cancer (TNBC). We performed p53 immunohistochemistry (IHC), nCounter mRNA expression assay, and DNA sequencing to determine the relationship between TP53 alteration and clinical outcomes of TNBC patients. Seventy-seven of 174 TNBC patients were found to harbor a TP53 mutation. Patients with missense mutations showed high protein expression in contrast to patients with deletion mutations (positivity of IHC: wild type vs. missense vs. deletion mutation, 53.6% vs. 89.8% vs. 25.0%, respectively; p < 0.001). TP53 mRNA expression was influenced by mutation status (mRNA expression [median]: wild type vs. missense vs. deletion mutation, 207.36± 132.73 vs. 339.61±143.21 vs. 99.53±99.57, respectively; p < 0.001). According to survival analysis, neither class of mutation nor protein or mRNA expression status had any impact on patient prognosis. In subgroup analysis, low mRNA expression was associated with poor prognosis in patients with a TP53 missense mutation (5-year distant recurrence-f...Continue Reading
References
Feb 20, 1992·International Journal of Cancer. Journal International Du Cancer·A M ThompsonC M Steel
Dec 10, 1990·Science·D MalkinM A Tainsky
Feb 7, 1997·Cell·A J Levine
May 13, 1999·Nature Genetics·X XuC X Deng
Nov 5, 1999·Advances in Cancer Research·P Hainaut, M Hollstein
Dec 1, 2000·Nature·B VogelsteinA J Levine
Nov 6, 2001·Nature Genetics·J JonkersA Berns
Jun 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Shunsuke KatoChikashi Ishioka
Dec 21, 2004·Cell·Gene A LangGuillermina Lozano
Sep 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lance D MillerJonas Bergh
Feb 22, 2007·Human Mutation·Audrey PetitjeanMagali Olivier
Feb 19, 2008·Nature Biotechnology·Gary K GeissKrassen Dimitrov
Jan 27, 2010·Oncogene·E Soto-Reyes, F Recillas-Targa
Jan 28, 2010·British Journal of Cancer·L BakerA M Thompson
Jun 3, 2011·The Journal of Clinical Investigation·Brian D LehmannJennifer A Pietenpol
Aug 5, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Ricardo Saldaña-Meyer, Félix Recillas-Targa
Apr 13, 2012·Nature·Sohrab P ShahSamuel Aparicio
Jun 23, 2012·Nature·Philip J StephensMichael R Stratton
Sep 25, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
Jan 30, 2013·PloS One·Frédérique VégranSarab Lizard-Nacol
Mar 22, 2013·Database : the Journal of Biological Databases and Curation·Dongwan HongJeong-Sun Seo
Jun 10, 2014·Acta Oncologica·Hans P EikesdalPer E Lønning
Dec 30, 2014·International Journal of Cancer. Journal International Du Cancer·Yeon Hee ParkYoung-Hyuck Im
Sep 4, 2015·Nature·Jiajun ZhuShelley L Berger
Citations
Jun 10, 2016·Annals of Surgical Oncology·Min Chong KimYoung Kyung Bae
Oct 30, 2016·Cancer Letters·Jingwen XuYingliang Wu
Aug 18, 2016·Molecular Carcinogenesis·Ming ZhaoXiaohe Yang
Jul 30, 2017·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Táya F OliveiraAna Maria R Ferreira
Dec 12, 2018·The Kaohsiung Journal of Medical Sciences·Soo Youn BaeSeok Jin Nam
May 3, 2019·Medicine·Jing-Ping LiYun-Jiang Liu
Apr 11, 2017·Oncology Reports·Jisela Dimas-GonzálezAlfredo Lagunas-Martínez
Jun 21, 2019·PloS One·Fabiola GiudiciBruna Scaggiante
Apr 22, 2017·Oncotarget·Ji-Yeon KimYeon Hee Park
Jan 2, 2018·Oncotarget·Zhi-Hua LiYa-Li Cao
May 22, 2020·Cancer Communications·Zongbi YiBinghe Xu
Sep 14, 2017·Nature Communications·Xi-Xi ChenMu-Sheng Zeng
Jul 22, 2017·Scientific Reports·Zongbi YiBinghe Xu
Mar 22, 2019·British Journal of Cancer·Hyeon Jeong OhGyeong Hoon Kang
Feb 25, 2017·PloS One·Yunbao PanYongchang Wei
Apr 3, 2019·BMC Cancer·Paul B MullanNiamh E Buckley
Apr 3, 2019·Veterinary Sciences·John S MundayNeroli A Thomson
Mar 29, 2018·Breast Cancer Research and Treatment·Elisabetta MunzoneMarco Colleoni
Apr 5, 2018·Oncology Letters·Yanli LuoGuang Liu
Sep 29, 2020·Cancer Biomarkers : Section a of Disease Markers·Heyan ChenHuimin Zhang
Jan 27, 2020·Breast Cancer Research and Treatment·Feng ZengJun Wang
Nov 30, 2019·Cancer Research·Gu XiaoJill Bargonetti
Jan 8, 2021·Biology of Sex Differences·Lauren J MillsLindsay A Williams
Feb 18, 2020·Trends in Cancer·Ashkan ShahbandiJames G Jackson
Apr 4, 2021·Diagnostics·Patrizia QuerzoliElisabetta Kuhn
May 1, 2021·Pharmaceutics·Dharambir KashyapAnupam Bishayee
May 11, 2021·Frontiers in Oncology·Weikai XiaoNing Liao
May 3, 2021·Gynécologie, Obstétrique, Fertilité & Sénologie·M OsadaC Mathelin
Jul 25, 2021·Cancers·Reyhaneh Farghadani, Rakesh Naidu
Aug 27, 2021·Veterinary Sciences·Wachiraphan SupsavhadThomas J Rosol