Abstract
We report seven patients with both myelodysplastic syndrome (MDS) and inflammatory bowel disease (IBD): Crohn's disease in six cases, ulcerative colitis in one case. We describe their characteristics, and those of 10 previously published similar cases are presented here. Median age at diagnosis of IBD (61 years) was high, as compared to the usual age at diagnosis of IBD. IBD was diagnosed first in nine cases, MDS first in one patient, and both diseases were diagnosed simultaneously in seven cases. Concerning IBD, there was a strong predominance of Crohn's disease (15/17 cases), with an unusually high frequency of colonic involvement (11/15 cases). MDS, in 12/17 cases, showed no excess of marrow blasts. Cytogenetic analysis was abnormal in five of the 13 evaluable cases. These observations suggest that the association between MDS and IBD may not be fortuitous in some cases, and that, in particular, patients with IBD and anemia of nonobvious origin should be evaluated for MDS. The pathogenesis of those associations, however, remains unclear.
Citations
Oct 10, 2006·International Journal of Colorectal Disease·Pietro CrispinoPaolo Paoluzi
Oct 25, 2007·Leukemia·J-J KiladjianA Caignard
Sep 13, 2002·Pediatrics International : Official Journal of the Japan Pediatric Society·Masaki YamamotoMitsuomi Kaimori
Jul 27, 2002·Journal of Pediatric Gastroenterology and Nutrition·Jolie LimonDaniel C West
May 25, 1999·Inflammatory Bowel Diseases·G C HarewoodW J Sandborn
Jun 1, 2004·Inflammatory Bowel Diseases·R M Hoffmann, W Kruis
Aug 19, 2014·Clinical Journal of Gastroenterology·Changmei HuJirong Huo
Dec 18, 2007·Digestive Diseases and Sciences·Zhifeng WangYulan Liu
Jul 20, 2006·Pediatric Hematology and Oncology·Sergio Carlos NahasVicente Odoni
Sep 6, 2006·Gastroenterology Clinics of North America·Sonia Friedman
Aug 22, 2015·Journal of Crohn's & Colitis·Vito AnneseUNKNOWN ECCO
Jan 9, 2007·Alimentary Pharmacology & Therapeutics·S Kulnigg, C Gasche
Feb 1, 2011·British Journal of Haematology·Sylvain PilorgeSophie Park
Oct 11, 2001·Molecular Genetics and Metabolism·H YangJ I Rotter
Apr 8, 2015·Diagnostic and Interventional Imaging·A DohanP Soyer
Mar 13, 2015·Leukemia·I Gañán-GómezG Garcia-Manero
Mar 25, 2014·Lancet·Lionel AdèsPierre Fenaux
Sep 13, 2005·Oncogene·Charles R M Bangham, Mitsuhiro Osame
Oct 24, 2000·Oncogene·A S GabetE Wattel
Feb 6, 2020·Inflammatory Bowel Diseases·Yuanzun PengYinghong Wang
Mar 10, 2020·Medicine·Ying ZhangXiao-Lin Guo
Mar 10, 2001·Cancer·C N BernsteinA Wajda