Association between neck circumference and the risk of decreased estimated glomerular filtration rate in the general population of China: a cross-sectional study

Jing XueYiming Mu


Background: The burden of chronic kidney disease is increasing substantially worldwide. Neck circumference (NC), an anthropometric index for upper-body adiposity, has been recognized as an indicator of cardiometabolic diseases. However, the association between NC and renal dysfunction has not been fully disclosed. The aim of this study was to investigate the association between NC and estimated glomerular filtration rate (eGFR) in the general population in China. Methods: A total of 8805 participants (3322 men and 5483 women) were enrolled in this study. Logistic regression analysis was conducted to examine the association between NC and eGFR. The male and female subjects were divided into four groups according to the neck circumference quartiles. The primary outcome was defined as an eGFR ≤ 90 mL/min/1.73 m2.Results: Logistic regression analysis revealed that in both sexes, higher neck circumference was significantly associated with a higher risk of decreased eGFR even after fully adjusting for age; other anthropometric indexes, including body mass index and waist to hip ratio; traditional risk factors for chronic kidney diseases; and sociologic risk factors (Quartile1 as a reference; the odds ratios [95% confidence intervals]...Continue Reading

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