Association Between Neonatal Neuroimaging and Clinical Outcomes in Zika-Exposed Infants From Rio de Janeiro, Brazil

JAMA Network Open
Kara-Lee PoolMarcos Pone

Abstract

Congenital Zika virus (ZIKV) infection may present with a spectrum of clinical and neuroradiographic findings. To determine whether neuroimaging findings for infants with a history of ZIKV exposure are associated with infant clinical outcomes and gestational age at antenatal ZIKV infection. This cohort study retrospectively reviewed neuroimaging results (computed tomography and/or magnetic resonance imaging scans) of 110 ZIKV-exposed infants from a maternity and children's hospital in Rio de Janeiro, Brazil, following the 2015 to 2016 ZIKV epidemic. Neuroimaging from March 1, 2016, to June 30, 2017, was evaluated to determine whether findings were associated with clinical outcomes and the timing of maternal ZIKV infection. Data were analyzed from July 1, 2017, to August 30, 2018. Neuroimaging (computed tomography and/or magnetic resonance imaging) was performed on ZIKV-exposed infants after birth. Blood and/or urine specimens from mothers and infants were tested for ZIKV by polymerase chain reaction assay. Neuroimaging studies were evaluated for structural abnormalities and other forms of brain injury. A total of 110 infants with a mean (SD) gestational age of 38.4 (2.1) weeks had neuroimaging and clinical outcome data reviewed...Continue Reading

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Jul 8, 2020·JAMA Network Open·Jessica S CranstonMaria Elisabeth Lopes Moreira
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Methods Mentioned

BETA
PCR
sedation

Software Mentioned

- 21st
Intergrowth
SAS

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