Association between neuroticism and amygdala responsivity emerges under stressful conditions

NeuroImage
Daphne EveraerdGuillén Fernández

Abstract

Increased amygdala reactivity in response to salient stimuli is seen in patients with affective disorders, in healthy subjects at risk for these disorders, and in stressed individuals, making it a prime target for mechanistic studies into the pathophysiology of affective disorders. However, whereas individual differences in neuroticism are thought to modulate the effect of stress on mental health, the mechanistic link between stress, neuroticism and amygdala responsivity is unknown. Thus, we studied the relationship between experimentally induced stress, individual differences in neuroticism, and amygdala responsivity. To this end, fearful and happy faces were presented to a large cohort of young, healthy males (n=120) in two separate functional MRI sessions (stress versus control) in a randomized, controlled cross-over design. We revealed that amygdala reactivity was modulated by an interaction between the factors of stress, neuroticism, and the emotional valence of the facial stimuli. Follow-up analysis showed that neuroticism selectively enhanced amygdala responses to fearful faces in the stress condition. Thus, we show that stress unmasks an association between neuroticism and amygdala responsivity to potentially threatenin...Continue Reading

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Citations

Sep 1, 2015·Trends in Cognitive Sciences·Adam M PerkinsDean Mobbs
Jun 16, 2016·Journal of Psychiatric Research·Isabelle E BauerJair C Soares
Dec 17, 2017·Scientific Reports·Silke KlamerThomas Ethofer
Oct 3, 2020·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Omer Van den BerghCristina Ottaviani
Jan 12, 2019·Journal of Neural Transmission·Hannes NoackBirgit Derntl
Oct 11, 2017·Social Cognitive and Affective Neuroscience·Sarah J KannHoi-Chung Leung
Apr 10, 2019·Proceedings of the National Academy of Sciences of the United States of America·Meichen YuYvette I Sheline
Apr 13, 2017·Social Cognitive and Affective Neuroscience·Nils KohnGuillén Fernández
Dec 19, 2017·Human Brain Mapping·Indira TendolkarGuillén Fernández

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