Association between NLPR1, NLPR3, and P2X7R Gene Polymorphisms with Partial Seizures

BioMed Research International
Haidong WangPei Jiang

Abstract

Objectives. Clinical and experimental evidence has clarified that the inflammatory processes within the brain play a pivotal role in the pathophysiology of seizures and epilepsy. Inflammasomes and P2X7 purinergic receptor (P2X7R) are important mediators during the inflammatory process. Therefore, we investigated the possible association between partial seizures and inflammasomes NLPR1, NLRP3, and P2X7R gene polymorphisms in the present study. Method. A total of 163 patients and 201 health controls were enrolled in this study and polymorphisms of NLPR1, NLRP3, and P2X7R genes were detected using polymerase chain reaction- (PCR-) ligase detection reaction method. Result. The frequency of rs878329 (G>C) genotype with C (CG + CC) was significantly lower among patients with partial seizures relative to controls (OR = 2.033, 95% CI = 1.290-3.204, p = 0.002 for GC + CC versus GG). Intriguingly, we found that the significant difference of rs878329 (G>C) genotype and allele frequency only existed among males (OR = 2.542, 95% CI = 1.344-4.810, p = 0.004 for GC + CC versus GG), while there was no statistically significant difference among females. However, no significant results were presented for the genotype distributions of rs8079034, ...Continue Reading

References

Oct 6, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·K KobayashiE Oka
Nov 9, 2002·Epilepsia·Irene A W KotsopoulosJ André Knottnerus
Nov 24, 2005·Epilepsia·Annamaria Vezzani, Tiziana Granata
Jul 21, 2006·Annals of the New York Academy of Sciences·Martin SchmidtRainer H Straub
Nov 13, 2007·Journal of Endocrinological Investigation·A VerrottiF Chiarelli
Feb 16, 2008·Circulation Research·Michael T GanterJean-François Pittet
Jan 14, 2010·Epilepsia·Anthony K NgugiCharles R Newton
Mar 23, 2010·Cell·Kate Schroder, Jurg Tschopp
Dec 8, 2010·Nature Reviews. Neurology·Annamaria VezzaniTallie Z Baram
Feb 22, 2011·Trends in Immunology·Frank L van de VeerdonkLeo A B Joosten
May 13, 2011·Epilepsia·Tiziana GranataGiuliano Avanzini
Jun 10, 2014·The British Journal of Dermatology·A-K EkmanC Enerbäck
Jun 15, 2014·Pharmacological Reviews·Rachael BartlettRonald Sluyter
Sep 17, 2014·Trends in Pharmacological Sciences·Beáta Sperlágh, Peter Illes

❮ Previous
Next ❯

Citations

Mar 7, 2018·Molecular Neurobiology·Shalini Singh, Sushmita Jha
Oct 18, 2020·Biomolecules·Bianca VezzaniCarlotta Giorgi

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.