Association between non-alcoholic fatty liver disease and myocardial glucose uptake measured by 18F-fluorodeoxyglucose positron emission tomography.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
Kun TangLing Wang

Abstract

Non-alcoholic fatty liver disease (NAFLD) has emerged as an independent risk factor for cardiovascular diseases. However, there were few studies evaluating the condition of myocardial glucose metabolism in patients with NAFLD. Therefore, the aim of this study was to investigate the association between NAFLD and myocardial glucose uptake assessed by using 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) and whether or not alteration of myocardial glucose uptake could be an indicator linking to cardiac dysfunction in NAFLD individuals. A total of 743 asymptomatic subjects (201 with NAFLD, 542 without NAFLD) were retrospectively studied. The ratio of maximum myocardium FDG uptake to the mean standardized uptake value of liver (SUVratio) was calculated to estimate myocardial glucose uptake by using 18F-FDG PET. The diagnosis of fatty liver and fatty liver grading was confirmed by unenhanced CT according to diagnostic criterion of previous studies. The myocardial geometric and functional data were obtained by echocardiogram. Myocardial glucose uptake was significantly lower in individuals with NAFLD compared with those without fatty liver (P < .001). When analysis of association trend was performed, SUVratio quart...Continue Reading

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Citations

May 12, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Kun TangLing Wang
Jun 16, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·S M Clifford, D J Murphy
Jun 10, 2021·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Wael A AlJaroudi, Fadi G Hage

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