Association between non-alcoholic hepatic steatosis and hyper reactive blood pressure response on the exercise treadmill test

QJM : Monthly Journal of the Association of Physicians
A G LaurinaviciusR D Santos

Abstract

Non-alcoholic hepatic steatosis (HS) is associated with hypertension and increased cardiovascular risk. While Blood pressure hyper-reactive response (HRR) during peak exercise indicates an increased risk of incident hypertension and increased cardiovascular risk, no data on the association of non-alcoholic HS and HRR exists. In this study, we have evaluated the association of HS with HRR. We included 13 410 consecutive individuals with a mean age: 42.4  ±  8.9 years, 3561 (26.6%) female with normal resting blood pressure and without a previous diagnosis of hypertension, who underwent symptom limited exercise treadmill test, abdominal ultrasonography and clinical and laboratory evaluation. HS was detected by abdominal ultrasonography. HRR was defined by a peak exercise systolic blood pressure  >220 mmHg and/or elevation of 15 mmHg or more in diastolic blood pressure from rest to peak exercise. The prevalence of HS was 29.5% (n  =  3956). Overall, 4.6% (n  =  619) of the study population presented a HRR. Subjects with HS had a higher prevalence of HRR (8.1 vs. 3.1%, odds ratio 2.8, 95% CI 2.4-3.3, P  <  0.001). After adjustment for body mass index, waist circumference, fasting plasma glucose and low density lipoprotein cholestero...Continue Reading

References

Jan 1, 1984·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·J C ScatarigeR C Sanders
Nov 1, 1993·Circulation·D PerloffB Z Morgenstern
Dec 1, 1996·Circulation·T A Pearson
May 29, 1998·Circulation·P W WilsonW B Kannel
Apr 19, 2002·The New England Journal of Medicine·Paul Angulo
Aug 6, 2003·Medicine and Science in Sports and Exercise·Cora L CraigPekka Oja
Feb 3, 2007·Journal of Human Hypertension·M J Brookes, B T Cooper
Apr 28, 2007·World Journal of Gastroenterology : WJG·Masahide HamaguchiToshikazu Yoshikawa
Jun 5, 2007·Clinics in Liver Disease·Phunchai Charatcharoenwitthaya, Keith D Lindor
Dec 4, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nila RafiqZobair M Younossi
Feb 7, 2009·International Journal of Clinical Practice·N TzemosT M MacDonald
Oct 1, 2010·The New England Journal of Medicine·Giovanni TargherEnzo Bonora
May 7, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Chiadi E NdumeleRaul D Santos
May 25, 2011·Annals of Medicine·José A M CarvalhoRaul D Santos
May 28, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ruben HernaezJeanne M Clark
Jan 10, 2013·Current Opinion in Lipidology·Paul J Nestel, Ronald P Mensink
Jan 23, 2013·Nature Reviews. Endocrinology·Norbert Stefan, Hans-Ulrich Häring
Jul 24, 2013·Circulation·Gerald F FletcherUNKNOWN American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee of the Council on Clinical Cardiology,
Sep 10, 2013·The American Journal of Cardiology·Sunal S MakadiaRaul D Santos
Oct 1, 2013·Clinics and Research in Hepatology and Gastroenterology·Yan LiDongfeng Chen
Dec 24, 2013·The American Journal of Cardiology·Camille Michael MinderMichael J Blaha
Apr 29, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Siddharth SinghRohit Loomba
Jun 10, 2014·Journal of Gastroenterology and Hepatology·Jae-Hong RyooSung Keun Park
Aug 17, 2014·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Harshal R PatilRandall C Thompson
Oct 12, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·UNKNOWN Non-alcoholic Fatty Liver Disease Study GroupGiovanni Targher

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.