Association between non-Hodgkin lymphoma and haplotypes in the TNF region

British Journal of Haematology
Charlotte F SpinkGareth J Morgan

Abstract

The cytokines tumour necrosis factor-alpha (TNFalpha) and lymphotoxin-alpha (LTalpha) are known to play key roles in B-cell growth, differentiation and maturation. Genetic polymorphism within regulatory regions of these cytokine genes can alter expression levels and may be important in development of lymphoid malignancy. This study investigates a number of single nucleotide polymorphisms (SNPs) and microsatellite variants present within these genes in a large cohort of non-Hodgkin lymphoma (NHL) cases including 211 cases of follicular lymphoma (FL) and 281 cases of diffuse large B-cell lymphoma (DLBCL), and 478 unaffected controls. The study investigated whether particular alleles at these loci, or their combination across the TNF region in the form of haplotypes, may act as markers for predisposition and development of NHL. The study provided evidence for an influence of the TNF region in the susceptibility to NHL, whereby the loci -863, -857, TNFe and TNFd categorised five haplotype groups over which risk of both FL and DLBCL varied significantly. Prediction of disease risk was improved by the addition of loci to the haplotype, demonstrating the importance of considering the haplotype-specific context of the loci in genetic r...Continue Reading

References

Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·M C CarrollT Spies
Jan 1, 1986·Immunologic Research·B Beutler, A Cerami
May 1, 1995·British Journal of Haematology·M SchmidF Porzsolt
Jun 8, 2000·Bioinformatics·G R Abecasis, W O Cookson
Oct 24, 2003·American Journal of Human Genetics·Matthew Stephens, Peter Donnelly
Oct 1, 2004·Cancer Causes & Control : CCC·Eleanor V WillettEve Roman
Nov 16, 2004·Genetic Epidemiology·Daniel J Schaid

❮ Previous
Next ❯

Citations

Jan 21, 2010·Cancer Causes & Control : CCC·Pia FernbergKarin Ekström Smedby
Apr 8, 2010·Cancer Causes & Control : CCC·Yian GuAnne Zeleniuch-Jacquotte
Aug 6, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Brahim AissaniRichard A Kaslow
Nov 8, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·James R CerhanSusan L Slager
Jul 4, 2007·Haematologica·Christine F SkibolaAlexandra Nieters
May 22, 2013·Clinical & Developmental Immunology·J MorscioT Tousseyn
Jun 6, 2015·Leukemia & Lymphoma·Kaspar Rene NielsenHans Erik Johnsen
Jun 11, 2011·Best Practice & Research. Clinical Haematology·James R Cerhan
Aug 26, 2010·Human Immunology·Martin HersbergerNicole Probst-Hensch
Jul 4, 2009·British Journal of Haematology·Xueying Sharon LiangLynn R Goldin
Jun 11, 2009·European Journal of Haematology·Elisabeth AndrieEleni Th Petridou
Jan 24, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Charles G Mullighan, Peter G Bardy
Sep 11, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yong-Qiao HeWei-Hua Jia
Apr 27, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Brahim AissaniSadeep Shrestha
Feb 27, 2007·Genetic Epidemiology·F K MensahG R Law

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.