Association between non-invasive liver fibrosis scores and occurrence of health adverse outcomes in older people

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Antonio De VincentisClaudio Pedone

Abstract

The relation between liver fibrosis scores and health outcomes in older people has been barely investigated. We aimed to evaluate the association of four liver fibrosis scores (fibrosis-4 -FIB-4-, NAFLD fibrosis score -NFS-, BARD and aspartate aminotransferase/alanine aminotransferase ratio -AST/ALT-) with mortality and incident disability at 6 years in an older population. We studied 962 individuals aged ≥65 (mean age 74.4; female 55.5%) with a mean follow-up of 95.7 months, enrolled in the InCHIANTI study. The relationship between liver fibrosis scores and mortality and disability was assessed through Cox and log-binomial regressions. NFS and FIB-4 were associated with higher overall (aHR ranging 1.38-1.78 for intermediate risk of fibrosis and 1.60-2.02 for high risk) and cardiovascular (aHR ranging 1.76-2.90 for intermediate and 2.22-2.42 for high risk) mortality. AST/ALT and BARD were only associated with overall mortality. Only NFS and FIB-4 high risk classes were associated with incident disability (aRR ranging 1.93-2.76). Despite poor sensitivity, all scores showed high specificity (ranging 0.88-0.95). Higher risk of liver fibrosis is associated with higher risk of poor health outcomes. Liver fibrosis scores may help to ...Continue Reading

Citations

Aug 31, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Vincenzo SolfrizziUNKNOWN Italian Longitudinal Study on Aging Working Group
Mar 2, 2021·Journal of Diabetes and Its Complications·Antonio De VincentisUmberto Vespasiani-Gentilucci
Mar 23, 2021·Journal of Clinical and Experimental Hepatology·Ameer AbutalebEleanor Wilson
Jun 7, 2021·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Antonio De VincentisUmberto Vespasiani-Gentilucci

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