Association between obesity and biomarkers of inflammation and metabolism with cancer mortality in a prospective cohort study

Metabolism: Clinical and Experimental
Daniel T DibabaTomi Akinyemiju

Abstract

To investigate the association between biomarkers of inflammation and metabolic dysregulation and cancer mortality by obesity status. Data from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort was used to examine the associations between baseline biomarkers of inflammation (IL-6, IL-8, IL-10, and CRP) and metabolism (adiponectin, resisting and lipoprotein (a)) with cancer mortality among 1822 participants cancer-free at baseline. Weighted Cox proportional hazard regression with the robust sandwich method was used to estimate the hazard ratios and 95% confidence intervals (CIs) adjusting for baseline covariates and stratified by BMI (normal, overweight/obese) given the significant interaction between biomarkers and BMI (p < 0.1). During a mean follow-up of 8 years, there were statistically significant associations between cancer mortality and being in the highest vs. lowest tertile of IL-6 (HR: 5.3; 95% CI: 1.6, 17.8), CRP (HR: 3.4; 95% CI: 1.0, 11.2) and resistin (HR: 3.7; 95% CI: 1.2, 11.2) among participants with normal BMI. IL-6 was also associated with a 3-fold (HR: 3.5; 95% CI: 1.5, 8.1) increased risk of cancer mortality among participants with overweight/obesity; however, neither CRP nor resis...Continue Reading

References

Dec 21, 2002·International Journal of Cancer. Journal International Du Cancer·Roberto SalgadoLuc Y Dirix
Apr 25, 2003·The New England Journal of Medicine·Eugenia E CalleMichael J Thun
Jul 2, 2005·Neuroepidemiology·Virginia J HowardGeorge Howard
Feb 1, 2007·Cancer·Jennifer L Beebe-DimmerKathleen A Cooney
Jan 7, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lindsey EnewoldCurtis C Harris
Mar 3, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jason R JaggersSteven N Blair
May 27, 2009·Carcinogenesis·Francesco ColottaAlberto Mantovani
Jul 22, 2010·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Birgitta GrundmarkBjörn Zethelius
Dec 1, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Catherine DugganAnne McTiernan
May 7, 2011·British Journal of Pharmacology·Md S JamaluddinChangyi Chen
Jul 29, 2011·Annals of the New York Academy of Sciences·Alison E HarveyStephen D Hursting
Nov 6, 2012·Annual Review of Medicine·Candace A Gilbert, Joyce M Slingerland
Nov 9, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Young-Jin KoMinseon Park
Aug 31, 2013·Journal of the National Cancer Institute·Kathryn H SchmitzBettina F Drake
Sep 21, 2013·Cancer Causes & Control : CCC·Meira EppleinXiao-Ou Shu
May 29, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Abhishek GoyalAbby B Siegel
Mar 10, 2015·JAMA Internal Medicine·Michael J OrlichGary E Fraser
Jun 2, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Lukasz PietrzykKamil Torres
Jun 19, 2015·Physiological Reviews·Emily Jane Gallagher, Derek LeRoith
Jun 23, 2015·Diabetology & Metabolic Syndrome·Fatima Al Hannan, Kevin Gerard Culligan
Sep 19, 2015·Cancer Prevention Research·Dawn Q ChongAndrew T Chan
Dec 4, 2015·Cancer Medicine·Wahyu WulaningsihMieke Van Hemelrijck
May 20, 2016·Annual Review of Pathology·Tuo DengWilla A Hsueh
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Neeraj KumariAnant Narayan Bhatt
Jul 19, 2016·Current Opinion in Pharmacology·Ryan KolbWeizhou Zhang
Sep 8, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elizabeth M Cespedes FelicianoBette J Caan
Dec 3, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Neil M IyengarClifford A Hudis
Jan 18, 2017·Cancer Causes & Control : CCC·Wambui G Gathirua-MwangiJianjun Zhang
Nov 28, 2017·Obesity·Tomi AkinyemijuSusan C Gilchrist

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Citations

Aug 24, 2019·Frontiers in Oncology·Xiao Yang, Jianliu Wang
Jun 8, 2019·Metabolism: Clinical and Experimental·Olivia M FarrChristos S Mantzoros
Jun 26, 2021·Pharmacology & Therapeutics·Lysanne DesharnaisDaniela F Quail
Aug 3, 2021·The British Journal of Nutrition·Xiude LiWanshui Yang
Nov 13, 2019·Metabolism: Clinical and Experimental·Chrysoula BoutariChristos S Mantzoros

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