Association Between Obesity and Discordance in Fibrosis Stage Determination by Magnetic Resonance vs Transient Elastography in Patients With Nonalcoholic Liver Disease

Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Cyrielle CaussyR Loomba

Abstract

Magnetic resonance elastography (MRE) and transient elastography (TE) are noninvasive techniques used to detect liver fibrosis in nonalcoholic fatty liver disease. MRE detects fibrosis more accurately than TE, but MRE is more expensive, and the concordance between MRE and TE have not been optimally assessed in obese patients. It is important to determine under which conditions TE and MRE produce the same readings, so that some patients can simply undergo TE evaluation to detect fibrosis. We aimed to assess the association between body mass index (BMI) and discordancy between MRE and TE findings, using liver biopsy as the reference, and validated our findings in a separate cohort. We performed a cross-sectional study of 119 adults with nonalcoholic fatty liver disease who underwent MRE, TE with M and XL probe, and liver biopsy analysis from October 2011 through January 2017 (training cohort). MRE and TE results were considered to be concordant if they found patients to have the same stage fibrosis as liver biopsy analysis. We validated our findings in 75 adults with nonalcoholic fatty liver disease who underwent contemporaneous MRE, TE, and liver biopsy at a separate institution from March 2010 through May 2013. The primary outc...Continue Reading

Citations

Apr 3, 2020·Expert Opinion on Pharmacotherapy·Yoshio SumidaAtsushi Nakajima
Mar 27, 2018·Liver International : Official Journal of the International Association for the Study of the Liver·Salvatore PettaSilvio Buscemi
Mar 31, 2019·Nature Communications·Cyrielle CaussyRohit Loomba
Oct 8, 2020·Hepatology Communications·Joud ArnoukJaideep Behari
Oct 27, 2020·Endocrinology, Diabetes & Metabolism·Cyrielle Caussy, Lars Johansson
Feb 20, 2021·Journal of Clinical and Translational Hepatology·Ma Ai Thanda HanNikolaos Pyrsopoulos
Nov 10, 2021·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Nilay DanisRohit Loomba

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