Association between oxygen delivery and consumption in patients undergoing cardiac surgery. Is there supply dependence?

Anaesthesia and Intensive Care
P S MylesM R Buckland

Abstract

We studied the relationship between oxygen delivery (DO2) and consumption (VO2) in twenty patients undergoing cardiac surgery, in order to determine if VO2 was dependent on DO2 (pathological oxygen supply dependence). We measured VO2 from expired gas analysis (VO2G) and compared this to that calculated using the reverse Fick method (VO2F). Both VO2G and VO2F increased after cardiopulmonary bypass (P < 0.001), without change in DO2 (i.e. oxygen extraction ration increased). There was a significant relationship between changes in DO2 and VO2F, both before bypass (r = 0.74, P < 0.001) and after bypass (r = 0.69, P < 0.001), while changes in DO2 and VO2G had no such relationship (pre-bypass: r = 0.38, P = 0.094; post-bypass: r = 0.10, P = 0.68). There was poor agreement between VO2F and VO2G perioperatively. We could not demonstrate supply dependence in elective cardiac surgical patients.

References

Jun 1, 1988·Journal of Applied Physiology·D P NelsonP T Schumacker
Jun 1, 1988·Journal of Applied Physiology·R B Light
May 1, 1987·Journal of Applied Physiology·H H StrattonJ C Newell
Nov 1, 1987·Critical Care Medicine·O ChiaraL Gattinoni
Oct 1, 1973·Anesthesiology·R S WilsonF O Bowman
Dec 1, 1971·British Journal of Anaesthesia·E A HarrisA W Squire
Aug 1, 1983·Critical Care Medicine·K ShibutaniD V Bizzarri
Mar 1, 1981·Annals of Surgery·J P Archie
Oct 19, 1995·The New England Journal of Medicine·L GattinoniR Fumagalli
Oct 19, 1995·The New England Journal of Medicine·C Hinds, D Watson
Apr 1, 1995·Anaesthesia and Intensive Care·M Schneider
Jun 16, 1994·The New England Journal of Medicine·M A HayesD Watson
Dec 1, 1993·Journal of Critical Care·C A ManthousL D Wood

❮ Previous
Next ❯

Citations

May 23, 2002·Perfusion·Y M GanushchakD S de Jong
Jun 13, 2006·Transfusion Medicine·R D SlightP S Mankad
Jan 10, 2009·Artificial Organs·Robert D SlightPankaj S Mankad
Aug 29, 2020·European Journal of Anaesthesiology·Julia JakobssonErzsébet Bartha
Dec 6, 2008·Transfusion Medicine Reviews·Robert D SlightPankaj S Mankad

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.