Association Between P300 Responses to Auditory Oddball Stimuli and Clinical Outcomes in the Psychosis Risk Syndrome.

JAMA Psychiatry
Holly K HamiltonDaniel H Mathalon

Abstract

In most patients, a prodromal period precedes the onset of schizophrenia. Although clinical criteria for identifying the psychosis risk syndrome (PRS) show promising predictive validity, assessment of neurophysiologic abnormalities in at-risk individuals may improve clinical prediction and clarify the pathogenesis of schizophrenia. To determine whether P300 event-related potential amplitude, which is deficient in schizophrenia, is reduced in the PRS and associated with clinical outcomes. Auditory P300 data were collected as part of the multisite, case-control North American Prodrome Longitudinal Study (NAPLS-2) at 8 university-based outpatient programs. Participants included 552 individuals meeting PRS criteria and 236 healthy controls with P300 data. Auditory P300 data of participants at risk who converted to psychosis (n = 73) were compared with those of nonconverters who were followed up for 24 months and continued to be symptomatic (n = 135) or remitted from the PRS (n = 90). Data were collected from May 27, 2009, to September 17, 2014, and were analyzed from December 3, 2015, to May 1, 2019. Baseline electroencephalography was recorded during an auditory oddball task. Two P300 subcomponents were measured: P3b, elicited by ...Continue Reading

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Citations

May 7, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniel C JavittThilo Womelsdorf
Jun 11, 2020·Psychiatry and Clinical Neurosciences·Naoya OribeMargaret A Niznikiewicz
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Jan 13, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Holly K HamiltonDaniel H Mathalon
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Aug 2, 2021·European Archives of Psychiatry and Clinical Neuroscience·GuiSen WuTianHong Zhang
Aug 14, 2021·NPJ Schizophrenia·Mitsuhiro MiyashitaMakoto Arai
Oct 2, 2021·The American Journal of Psychiatry·Daniel C Javitt

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