Association between pancreatic cystadenocarcinoma, malignant liver cysts, and polycystic disease of the kidney

Gastroenterology
Y NivG M Fraser

Abstract

Polycystic kidney disease is an autosomal dominant disease that may be associated with cystic disease of the liver. In women, the cysts may develop early and be more troublesome than in men. Cystadenocarcinoma of the pancreas is uncommon, comprising 1% of primary pancreatic malignancies. This case report is the first to describe a familial association between polycystic kidney disease and cystadenocarcinoma of the pancreas and liver in the English medical literature. A patient with autosomal dominant polycystic kidney disease (ADPKD) and multiple hepatic cysts developed cystadenocarcinoma of the pancreas with multiple malignant liver cysts. The patient's mother, sister, and niece had ADPKD, and the patient's sister also died of pancreatic cystadenocarcinoma. We believe that the development of these two disease entities in which the primary pathology is cyst formation has a genetic association.

Citations

Mar 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R K ChathaP A Gabow
Jul 5, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Adam E MikolajczykArlene B Chapman
Nov 24, 2011·Case Reports in Gastroenterology·Kenji MimatsuSadao Amano
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Aug 7, 1999·Medizinische Klinik·U Rosien, P Layer
Aug 31, 2000·Journal of the American Society of Nephrology : JASN·Dominique ChauveauJean-Pierre Grünfeld

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