Association between PCR ribotypes and antimicrobial susceptibility among Clostridium difficile isolates from healthcare-associated infections in South Korea

International Journal of Antimicrobial Agents
Jieun KimTae Yeal Choi

Abstract

In this study, the association between antimicrobial susceptibility, PCR ribotype and presence of the ermB gene in clinical isolates of Clostridium difficile was investigated. PCR ribotyping and ermB gene PCR were performed on 131 C. difficile isolates. The susceptibility of these isolates to metronidazole, vancomycin, piperacillin/tazobactam (TZP), clindamycin, moxifloxacin and rifaximin was also determined. Use of antibiotics within the previous 2 months was documented. Resistance rates to clindamycin, moxifloxacin and rifaximin were 67.9%, 62.6% and 19.1%, respectively. No metronidazole, vancomycin or TZP resistance was detected. Previous exposure to moxifloxacin was significantly correlated with resistance to this antibiotic, but prior use of clindamycin was not significantly correlated with clindamycin resistance. Sixty-four strains (48.9%) carried the ermB gene, of which all but one (98.5%) were resistant to clindamycin. The clindamycin resistance rates of the common PCR ribotypes (018, 017 and 001) were 91.4%, 100% and 84.2%, respectively, and their moxifloxacin resistance rates were 91.4%, 95.0% and 78.9%, respectively. Resistance rates to rifaximin were 5.7% and 95.0% in ribotype 018 and 017 strains, whilst none of the...Continue Reading

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Citations

Jul 3, 2013·Antimicrobial Resistance and Infection Control·Deirdre A CollinsThomas V Riley
Oct 12, 2013·Folia Microbiologica·Vladimir BeranJosef Tvrdik
Jun 5, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J KimH Pai
Dec 5, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Y KuwataR Saito
Dec 30, 2014·International Journal of Antimicrobial Agents·Papanin PutsathitThomas V Riley
Nov 5, 2016·Anaerobe·Fabrizio Barbanti, Patrizia Spigaglia
Feb 11, 2016·Therapeutic Advances in Infectious Disease·Patrizia Spigaglia
Sep 27, 2020·Antimicrobial Resistance and Infection Control·Mohammad SholehEbrahim Kouhsari
Jun 13, 2017·Antimicrobial Resistance and Infection Control·Papanin PutsathitThomas V Riley
Jun 24, 2016·Microbiology Spectrum·Jae Hyun ShinCirle A Warren

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