Abstract
In this study, the association between antimicrobial susceptibility, PCR ribotype and presence of the ermB gene in clinical isolates of Clostridium difficile was investigated. PCR ribotyping and ermB gene PCR were performed on 131 C. difficile isolates. The susceptibility of these isolates to metronidazole, vancomycin, piperacillin/tazobactam (TZP), clindamycin, moxifloxacin and rifaximin was also determined. Use of antibiotics within the previous 2 months was documented. Resistance rates to clindamycin, moxifloxacin and rifaximin were 67.9%, 62.6% and 19.1%, respectively. No metronidazole, vancomycin or TZP resistance was detected. Previous exposure to moxifloxacin was significantly correlated with resistance to this antibiotic, but prior use of clindamycin was not significantly correlated with clindamycin resistance. Sixty-four strains (48.9%) carried the ermB gene, of which all but one (98.5%) were resistant to clindamycin. The clindamycin resistance rates of the common PCR ribotypes (018, 017 and 001) were 91.4%, 100% and 84.2%, respectively, and their moxifloxacin resistance rates were 91.4%, 95.0% and 78.9%, respectively. Resistance rates to rifaximin were 5.7% and 95.0% in ribotype 018 and 017 strains, whilst none of the...Continue Reading
References
Jul 1, 1999·FEMS Microbiology Letters·P BidetJ C Petit
Nov 26, 1999·The New England Journal of Medicine·S JohnsonD N Gerding
Sep 1, 2004·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Jacques PépinDaniel Chouinard
Nov 24, 2004·International Journal of Antimicrobial Agents·Julian S BendleKhalid M Al-Shafi
Jul 9, 2005·The Journal of Hospital Infection·R John, J S Brazier
Dec 3, 2005·The New England Journal of Medicine·L Clifford McDonaldDale N Gerding
Jan 26, 2006·Journal of Medical Microbiology·Hanna PituchMiroslaw Luczak
Apr 6, 2006·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Matthew H SamoreStephan Harbarth
Feb 23, 2007·Journal of Clinical Microbiology·Hanna PituchAlex van Belkum
May 23, 2007·Antimicrobial Agents and Chemotherapy·David W HechtDale N Gerding
Sep 14, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·F BarbutUNKNOWN European Study Group on Clostridium difficile (ESGCD)
Sep 22, 2007·Infection·B RazaviL M Mundy
May 16, 2008·Journal of Medical Microbiology·Bo-Moon ShinJeong-Hwan Shin
Aug 12, 2008·The Journal of Antimicrobial Chemotherapy·Simon D BainesMark H Wilcox
Oct 31, 2008·The New England Journal of Medicine·Ciarán P Kelly, J Thomas LaMont
Dec 23, 2008·International Journal of Antimicrobial Agents·Haihui HuangCarl Erik Nord
Jan 15, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Scott R CurryLee H Harrison
May 15, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A GoorhuisE J Kuijper
Sep 8, 2009·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·T NorénM Unemo
Nov 28, 2009·Journal of Medical Microbiology·Surabhi K TaoriIan R Poxton
Jun 18, 2010·Journal of Clinical Microbiology·Patrizia SpigagliaPaola Mastrantonio
Sep 21, 2010·Anaerobe·Haihui HuangCarl Erik Nord
Oct 5, 2010·The Korean journal of laboratory medicine·Heejung KimKyungwon Lee
Nov 19, 2010·Lancet·Martijn P BauerUNKNOWN ECDIS Study Group
Mar 19, 2011·Journal of Medical Microbiology·Hanna PituchEd Kuijper
Jun 30, 2011·The Journal of Antimicrobial Chemotherapy·Katie SolomonLorraine Kyne
Sep 15, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A GoorhuisE J Kuijper
Oct 25, 2011·Journal of Korean Medical Science·Jieun KimJung Oak Kang
Citations
Jul 3, 2013·Antimicrobial Resistance and Infection Control·Deirdre A CollinsThomas V Riley
Oct 12, 2013·Folia Microbiologica·Vladimir BeranJosef Tvrdik
Jun 5, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J KimH Pai
Jun 8, 2014·Anaerobe·Danielle Angst SeccoRegina Maria Cavalcanti Pilotto Domingues
Apr 17, 2015·The Journal of Antimicrobial Chemotherapy·E ReigadasE Bouza
Dec 5, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Y KuwataR Saito
Sep 23, 2014·Anaerobe·Dominika LachowiczPiotr Obuch-Woszczatyński
Dec 30, 2014·International Journal of Antimicrobial Agents·Papanin PutsathitThomas V Riley
Jul 23, 2016·Genome Announcements·François WaselsPatrizia Spigaglia
Nov 5, 2016·Anaerobe·Fabrizio Barbanti, Patrizia Spigaglia
Dec 22, 2016·PloS One·Jieun KimHyunjoo Pai
Jan 8, 2016·Scientific Reports·Jing-Wei ChengYing-Chun Xu
Feb 11, 2016·Therapeutic Advances in Infectious Disease·Patrizia Spigaglia
Apr 14, 2017·Journal of Clinical Microbiology·Zhong PengXingmin Sun
Nov 23, 2013·Infection & chemotherapy·Jieun KimHyunjoo Pai
Sep 19, 2019·Antimicrobial Agents and Chemotherapy·Kotaro AokiKazuhiro Tateda
Feb 23, 2018·Journal of Clinical Microbiology·Ruxin LiJianhong Zhao
Sep 27, 2020·Antimicrobial Resistance and Infection Control·Mohammad SholehEbrahim Kouhsari
Jun 13, 2017·Antimicrobial Resistance and Infection Control·Papanin PutsathitThomas V Riley
Apr 24, 2018·BioMed Research International·Saeed S Banawas
Aug 17, 2019·Anaerobe·Cécile GateauFrédéric Barbut
Jun 24, 2016·Microbiology Spectrum·Jae Hyun ShinCirle A Warren
Jul 3, 2021·Antibiotics·Supapit WongkunaSurang Chankhamhaengdecha