Association between PD-L1 expression and driver gene status in non-small-cell lung cancer: a meta-analysis

Oncotarget
Bo LanKai Wang

Abstract

To assess the association between PD-L1 expression and driver gene mutations in patients with non-small-cell lung cancer (NSCLC). We performed a meta-analysis of 26 studies (7541 patients) which were published from 2015 to 2017. Pooled odds ratios (ORs) with 95% confidence intervals (CI) were calculated to describe the correlation. Subgroup analysis was performed based on population characteristics, types of PD-L1 antibodies and quality of individual studies. A lower frequency of PD-L1 positivity was observed in NSCLCs harboring EGFR mutation (OR: 0.64, 95% CI, 0.45-0.91,p= 0.014). A negative correlation was also found at 1% (OR: 0.35, 95% CI, 0.22-0.55,p= 0.000) and 50% (OR: 0.33, 95% CI, 0.14-0.81,p= 0.015) cutoff for PD-L1 positive, elderly age group (OR: 0.56, 95% CI, 0.35-0.89,p= 0.013), female dominant group (OR: 0.55, 95% CI, 0.29-0.94,p= 0.030) and smoker dominant group (OR: 0.52, 95% CI, 0.29-0.96,p= 0.035). No significant differences in PD-L1 expression were observed among patients with different ALK, BRAF, HER2, PIK3CA status and MET expression level. Higher level of PD-L1 was found in tumors with KRAS mutation (OR: 1.45, 95% CI, 1.18-1.80,p= 0.001). PD-L1 expression level was not significantly different between trip...Continue Reading

References

Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Sep 6, 2005·Cancer Research·Bruce E Johnson, Pasi A Jänne
Jul 29, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hakan AkcaJun Yokota
Jan 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yih-Leong ChangYung-Chie Lee
May 3, 2008·Mayo Clinic Proceedings·Julian R MolinaAlex A Adjei
Jan 17, 2012·Journal of the National Cancer Institute·Nathan T IhleGarth Powis
Feb 20, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ching-Yao YangPan-Chyr Yang
Sep 27, 2014·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Thomas E Stinchcombe, Gary L Johnson
Oct 29, 2014·British Journal of Cancer·A D'InceccoF Cappuzzo
Feb 7, 2015·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Nan ChenLi Zhang
Feb 11, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Moon-Young KimDoo Hyun Chung
Mar 31, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yang QuLixin Wei
Apr 12, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yih-Leong ChangPan-Chyr Yang
May 23, 2015·Biochemical and Biophysical Research Communications·Kailong LinBo Zhu
May 29, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Keiichi OtaIsamu Okamoto
May 31, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Wendy A CooperRichard A Scolyer
Jun 2, 2015·The New England Journal of Medicine·Julie BrahmerDavid R Spigel
Jul 18, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jaemoon KohDoo Hyun Chung
Aug 28, 2015·PloS One·Lars Henning SchmidtWolfgang Hartmann
Sep 29, 2015·The New England Journal of Medicine·Hossein BorghaeiJulie R Brahmer
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Feb 24, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Ching-Yao YangPan-Chyr Yang
May 27, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Justin F GainorMari Mino-Kenudson
Jun 3, 2016·CA: a Cancer Journal for Clinicians·Kimberly D MillerAhmedin Jemal
Oct 25, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kazuki TakadaYoshihiko Maehara
Jul 21, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·Xiaoli JiaChunyan Wu
Jul 29, 2016·Oncoimmunology·Andreas H ScheelJürgen Wolf
Aug 12, 2016·Japanese Journal of Clinical Oncology·Kentaro InamuraYuichi Ishikawa
Oct 25, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Tiffany G HuynhMari Mino-Kenudson
Oct 11, 2016·The New England Journal of Medicine·Martin ReckUNKNOWN KEYNOTE-024 Investigators

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Citations

Sep 29, 2020·Nature Cancer·Shruthy SureshKathryn A O'Donnell
Aug 1, 2018·Cancers·Yosuke Miura, Noriaki Sunaga
Jun 29, 2018·Current Treatment Options in Oncology·Jacqueline V Aredo, Sukhmani K Padda
Jan 29, 2020·Virchows Archiv : an International Journal of Pathology·Eleni A KaratrasoglouAngelica A Saetta
Aug 25, 2018·Molecular Cancer·Ming YiKongming Wu
Feb 12, 2019·Experimental Hematology & Oncology·Vaibhav VermaAbhijai Singh
Jan 2, 2021·Frontiers in Oncology·Andrés F CardonaRafael Rosell
Apr 11, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A L NoordhofW H van Geffen
Mar 10, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Noura J ChoudhuryGregory J Riely
Jun 3, 2021·International Journal of Molecular Sciences·Yi-Chun ChaoCheng-Wei Lin
Sep 11, 2018·Clinical Lung Cancer·Bojan ZaricMartin Filipits

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