Association between phenotypic familial hypercholesterolaemia and telomere length in US adults: results from a multi-ethnic survey

European Heart Journal
Maciej BanachGerald F Watts

Abstract

Familial hypercholesterolaemia (FH) accelerates atherosclerotic cardiovascular disease (ASCVD) and accordingly is the most potent hereditary cause of premature coronary heart disease. The association between telomere length (TL), a biological index of ageing, and FH has not been hitherto investigated. We addressed this question using data from the US National Health and Education National Surveys (NHANES, 1999-2002). We included individuals, who had TL measurements (with quantitative polymerase chain reaction method) and a phenotypic diagnosis of FH based on the Dutch Lipid Clinic Network (DLCN) criteria. Sample weights were applied for unequal probabilities of selection, non-response bias, and oversampling by complex sample analysis. The adult prevalence of FH in NHANES was 0.43% [95% confidence interval (95% CI) 0.33-0.57]. The frequencies of probable FH (mean DLCN score: 6.2) and definite FH (mean DLCN score: 8.9) were 0.42% (95% CI 0.32-0.48) and 0.03% (95% CI 0.02-0.06), respectively. Subjects with FH had a higher prevalence of non-communicable diseases (hypertension, diabetes 2 type, and obesity) and early atherosclerosis (2.9% in overall population vs. 42.2% in FH). Overall, the mean TL in the non-FH population was 1.09 ...Continue Reading

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Citations

Jan 3, 2019·European Heart Journal·Željko ReinerUlf Landmesser
Jan 3, 2019·European Heart Journal·Thomas F Lüscher
Feb 25, 2021·European Journal of Preventive Cardiology·Maciej Banach, Peter E Penson
Mar 25, 2020·Trends in Cardiovascular Medicine·Vanessa BianconiUNKNOWN International Lipid Expert Panel (ILEP)
Mar 3, 2020·Archives of Medical Science : AMS·Jędrzej DraganMaciej Salagierski

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