Association between phylogeny, virulence potential and serovars of Salmonella enterica

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Eva LitrupEva M Nielsen

Abstract

Salmonella enterica subsp. enterica is one of the leading causes of zoonotic food-borne disease worldwide. The consequence of these infections is a serious impact on economics of the society in the form of lost productivity and expenses for medical care. The objective of this study was to analyze the difference in genomic content between selected serovars, especially the content of pathogenicity genes and this was done with a DNA microarray. Furthermore, we investigated the phylogenetic relationship between serovars using multilocus sequence typing (MLST). We chose serovars Typhimurium and Enteritidis as they are responsible for 75% of human infections in Europe. Additionally, we included serovars Derby, Dublin, Saintpaul, 4,5,12:i:-, Java and 4,5,12:b:- which are suspected to have different degrees of virulence to humans. MLST analysis clustered strains according to serovar with the exception of Java and Derby. DNA microarray clustered strains according to serovar and serogroup except for serovar 4,5,12:b:-. Differences in content of pathogenicity related genes between serovars with various host preferences and virulence towards humans were not observed. However, our strains from the supposedly less virulent serovar Derby lack...Continue Reading

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Citations

Jun 25, 2013·Applied and Environmental Microbiology·Anne ToboldtBurkhard Malorny
Apr 27, 2013·Enfermedades infecciosas y microbiología clínica·María de ToroYolanda Sáenz
Sep 16, 2011·International Journal of Food Microbiology·Elisabeth HauserBurkhard Malorny
Oct 18, 2011·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Chad LaingVictor P J Gannon
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May 16, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Grazielle Lima RodriguesCarlos Adam Conte-Junior
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Feb 19, 2019·EFSA Journal·UNKNOWN EFSA Panel on Biological Hazards (EFSA BIOHAZ Panel)Robert Davies
Sep 30, 2021·Applied and Environmental Microbiology·Zhiying WangMichael G Gänzle

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