Association between plasma asymmetrical dimethylarginine activity and severity of aortic valve stenosis

Journal of Cardiovascular Medicine
Goksel CagirciRamazan Akdemir

Abstract

Aortic valve stenosis is the most common valvular heart disease in the Western world. The most common cause of aortic valve stenosis in adults is calcification of a normal trileaflet or congenital bicuspid valve. Calcific aortic valve stenosis is an active disease process characterized by mechanical stress, endothelial damage, lipid accumulation, inflammation, synthesis of extracellular matrix proteins, and calcification, reminiscent of atherosclerosis in many aspects. Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase which reduces the bioavailability of nitric oxide and begets endothelial dysfunction. The goal of this study was to examine the association between ADMA activity and severity of aortic valve stenosis. One hundred and nine patients were included in this study. Patients were grouped as those with mild aortic stenosis (42 patients, group 1), moderate aortic stenosis (36 patients, group 2), and severe aortic stenosis (31 patients, group 3). ADMA activity was measured by ELISA kit. Mean ADMA activity in group 3 was significantly higher than that in groups 1 and 2 (1.94 ± 0.45 vs. 0.87 ± 0.37 micromol/l, P < 0.001 and 1.94 ± 0.45 vs. 1.34 ± 0.52 micromol/l, P < 0.001, respectively)...Continue Reading

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May 28, 2011·Circulation Research·Jordan D MillerDonald D Heistad
Oct 8, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marcello RattazziPaolo Pauletto
Nov 12, 2015·Advanced Drug Delivery Reviews·Shouka Parvin NejadCraig A Simmons
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Feb 2, 2011·Advanced Drug Delivery Reviews·Jonathan T ButcherLaura A Hockaday
Sep 10, 2013·Interactive Cardiovascular and Thoracic Surgery·Viviana CavalcaAlessandro Parolari
Feb 14, 2018·Journal of the American Heart Association·Isabella AlbaneseAdel Schwertani

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