Association between plasma ceramides and inducible myocardial ischemia in patients with established or suspected coronary artery disease undergoing myocardial perfusion scintigraphy

Metabolism: Clinical and Experimental
Alessandro MantovaniGiovanni Targher

Abstract

Recent studies have suggested that specific plasma ceramides are independently associated with major adverse cardiovascular events in patients with coronary artery disease (CAD), but it is currently unknown whether plasma ceramide levels are associated with stress-induced reversible myocardial ischemia. We measured six previously identified high-risk plasma ceramide molecules [Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/20:0), Cer(d18:1/22:0), Cer(d18:1/24:0), and Cer(d18:1/24:1)] in 167 consecutive patients with established or suspected CAD who underwent either exercise or dypiridamole myocardial perfusion scintigraphy (MPS) for various clinical indications. Plasma ceramide levels were measured by a targeted liquid chromatography-tandem mass spectrometry assay both at baseline and after MPS. Seventy-eight patients had inducible myocardial ischemia on stress MPS. Women had significantly higher circulating levels of basal and post-stress Cer(d18:1/16:0) and Cer(d18:1/18:0) compared to men, whereas all other plasma ceramides did not differ between the sexes. Of the six measured plasma ceramides, basal Cer(d18:1/24:1) showed the strongest association with the presence of stress-induced myocardial perfusion defects in univariate an...Continue Reading

Citations

Dec 21, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Alessandro MantovaniGiovanni Targher
Sep 25, 2019·International Journal of Molecular Sciences·Antonino TuttolomondoAntonio Pinto
Jan 24, 2019·International Journal of Molecular Sciences·Angel CogolludoLaura Moreno
Apr 20, 2019·Journal of Clinical Medicine·Margaret A DrazbaMelissa Ventura Marra

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