Association between plasma high-sensitivity C-reactive protein and insulin resistance and white matter lesions in Japanese type 2 diabetic patients

Diabetes Research and Clinical Practice
Futoshi AnanHironobu Yoshimatsu

Abstract

The presence of white matter lesions (WML) is an important prognostic factor for the development of stroke. High-sensitivity C-reactive protein (HSCRP), which is associated with diabetes, has been flagged as a novel predictor for cerebrovascular events. This preliminary study was therefore designed to test the hypothesis that the presence of WML correlates with HSCRP and insulin resistance in type 2 diabetic patients not receiving insulin treatment. Based on brain magnetic resonance imaging (MRI) findings, 102 type 2 diabetic patients were divided into two groups; a WML-positive group (59+/-6 years, mean+/-SD, n=40) and a WML-negative group (58+/-6 years, n=62). The level of blood glucose was assessed by fasting plasma glucose (FPG), fasting immunoreactive insulin (F-IRI), homeostasis model assessment (HOMA) index, and Hemoglobin A1c (HbA1c). The body mass index was higher in the WML-positive group than in the WML-negative group (p<0.05). Plasma levels of triglycerides were higher while high-density lipoprotein cholesterol (HDL-C) was lower in the WML-positive group than in the WML-negative group (p<0.01 and p<0.005, respectively). Fasting plasma glucose (p<0.005), insulin concentrations (p<0.0001), HOMA index (p<0.0001), and H...Continue Reading

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Citations

Dec 17, 2015·Geriatrics & Gerontology International·Yoshiaki Tamura, Atsushi Araki
Aug 29, 2014·The Lancet. Diabetes & Endocrinology·Stefan L C GeijselaersGeert Jan Biessels
Oct 18, 2018·Diabetes Care·Marnix J M van AgtmaalCoen D A Stehouwer
Apr 3, 2020·The International Journal of Neuroscience·Liming CaoZhishan Zhu

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