Abstract
The presence of white matter lesions (WML) is an important prognostic factor for the development of stroke. High-sensitivity C-reactive protein (HSCRP), which is associated with diabetes, has been flagged as a novel predictor for cerebrovascular events. This preliminary study was therefore designed to test the hypothesis that the presence of WML correlates with HSCRP and insulin resistance in type 2 diabetic patients not receiving insulin treatment. Based on brain magnetic resonance imaging (MRI) findings, 102 type 2 diabetic patients were divided into two groups; a WML-positive group (59+/-6 years, mean+/-SD, n=40) and a WML-negative group (58+/-6 years, n=62). The level of blood glucose was assessed by fasting plasma glucose (FPG), fasting immunoreactive insulin (F-IRI), homeostasis model assessment (HOMA) index, and Hemoglobin A1c (HbA1c). The body mass index was higher in the WML-positive group than in the WML-negative group (p<0.05). Plasma levels of triglycerides were higher while high-density lipoprotein cholesterol (HDL-C) was lower in the WML-positive group than in the WML-negative group (p<0.01 and p<0.005, respectively). Fasting plasma glucose (p<0.005), insulin concentrations (p<0.0001), HOMA index (p<0.0001), and H...Continue Reading
References
Oct 1, 1991·The Journal of Clinical Investigation·N A NelkenJ N Wilcox
Mar 1, 1991·Diabetes Care·R A DeFronzo, E Ferrannini
Jun 1, 1990·Diabetes Care·R W Stout
Dec 1, 1990·Hypertension·K ShimadaT Ozawa
Jul 1, 1985·Diabetologia·D R MatthewsR C Turner
Jul 1, 1995·Stroke; a Journal of Cerebral Circulation·L Pantoni, J H Garcia
Jul 1, 1994·Neurology·M M BretelerJ van Gijn
Aug 1, 1996·Stroke; a Journal of Cerebral Circulation·W T LongstrethL Fried
Dec 5, 1998·Diabetes Care·D LiaoA R Sharrett
Jan 14, 1999·The New England Journal of Medicine·R Ross
Sep 14, 1999·Circulation·P Libby, P M Ridker
Feb 15, 2000·Circulation·K KubokiG L King
Jul 26, 2000·Diabetes·H O SteinbergA D Baron
Nov 1, 2000·Circulation·V PasceriE T Yeh
Dec 29, 2000·Diabetes Care·A TaniguchiY Nakai
Dec 29, 2000·Diabetes Care·M FröhlichW Koenig
Jul 4, 2001·JAMA : the Journal of the American Medical Association·M A AlbertUNKNOWN PRINCE Investigators
Nov 28, 2001·Circulation·C Guijarro
Feb 6, 2002·Circulation·Guido ArcaroRiccardo C Bonadonna
Mar 5, 2002·Journal of Hypertension·Cristina SierraAntonio Coca
Jul 2, 2002·JAMA : the Journal of the American Medical Association·Tien Yin WongUNKNOWN ARIC Investigators. Atheroslerosis Risk in Communities Study
Sep 18, 2002·Circulation·Senthil Kumar VenugopalIshwarlal Jialal
Jan 23, 2003·Brain : a Journal of Neurology·Ahamad HassanHugh S Markus
Jan 29, 2003·Circulation·Thomas A PearsonUNKNOWN American Heart Association
Apr 12, 2003·Stroke; a Journal of Cerebral Circulation·Sarah E VermeerUNKNOWN Rotterdam Scan Study
Aug 28, 2003·Diabetes Care·Noriko SatohKazuwa Nakao
Oct 22, 2003·Circulation·Matteo CesariMarco Pahor
Feb 28, 2004·Diabetes·Reinhold SchmidtUNKNOWN CASCADE Consortium
Mar 5, 2005·Stroke; a Journal of Cerebral Circulation·Taku HoshiMasatsugu Hori
Aug 3, 2005·Circulation·E J van DijkM M B Breteler
May 11, 2006·Nitric Oxide : Biology and Chemistry·Claudio NapoliLouis J Ignarro
Feb 27, 2007·Journal of the Neurological Sciences·Manabu WadaTakeo Kato
May 12, 2007·Diabetologia·C JongenUNKNOWN Utrecht Diabetic Encephalopathy Study Group
Citations
Jun 15, 2011·Cardiovascular Diabetology·Ryuichi KawamotoNobuyuki Ohtsuka
Jul 12, 2013·International Journal of Endocrinology·Aleksandra JoticNebojsa M Lalic
Dec 17, 2015·Geriatrics & Gerontology International·Yoshiaki Tamura, Atsushi Araki
Aug 29, 2014·The Lancet. Diabetes & Endocrinology·Stefan L C GeijselaersGeert Jan Biessels
Oct 15, 2014·Diabetes Research and Clinical Practice·Amal ZaghloulShirin H Teama
Jun 19, 2017·European Neurology·Yuan GaoJialing Wu
Jul 28, 2017·Neurological Research·Dongzhe HouJialing Wu
Oct 18, 2018·Diabetes Care·Marnix J M van AgtmaalCoen D A Stehouwer
Aug 4, 2018·Current Medical Science·You-Ping ZhangSha-Bei Xu
Mar 15, 2018·Medicine·Cheng-Jin YouGuo-Zhong Li
Nov 12, 2019·Frontiers in Neuroscience·Xiaohui WangXu Cui
Apr 3, 2020·The International Journal of Neuroscience·Liming CaoZhishan Zhu