Abstract
D-dimer and fibrinogen/fibrin degradation products (FDP) levels are elevated in subjects with thromboembolic disorders, and the assays for detection of D-dimer and FDP are used in many laboratories for the investigation of these disorders. The aim of this study was to evaluate the association between the plasma levels of D-dimer and FDP in the investigation of thromboembolic disorders. D-dimer and FDP immunoassays were performed in 217 consecutive blood samples from subjects with suspected of thromboembolic disorders by use of Liatest D-dimer and Plasma FDP. FDP results were classified in: <5, 5-20, >20 microg/mL, and D-dimer levels obtained in these groups ranged to 350-1,210 ng/mL, 420-1,960 ng/mL, and 1,190-51,170 ng/mL, respectively. A significant association between D-dimer levels and the reaction times necessary to occur agglutination in latex agglutination test for FDP was observed. There was an association between plasma levels of D-dimer and FDP. The preliminary determination of FDP levels could be useful because it allows estimating the D-dimer levels before of the automated systems analysis, reducing costs associated to dilutions of plasma samples.
References
Dec 1, 1992·Cancer·E C GabazzaS Suzuki
Jan 26, 1991·Lancet·H BounameauxP F Unger
Jan 1, 1989·British Journal of Haematology·J T WildeF E Preston
Nov 1, 1986·Circulation·C W FrancisV J Marder
Apr 1, 1993·Chest·S R Deitcher, P R Eisenberg
Jan 1, 1995·Respiration; International Review of Thoracic Diseases·J FloresL J García Frade
Aug 1, 1997·American Journal of Respiratory and Critical Care Medicine·A PerrierH Bounameaux
Jun 10, 1998·American Journal of Clinical Pathology·M Escoffre-BarbeD Mottier
Jul 9, 1998·American Journal of Respiratory and Critical Care Medicine·E OgerD Mottier
Aug 13, 1998·Thrombosis Research·M DuetO Mundler
Mar 24, 1999·Angiology·O BjörgellD Bergqvist
Jul 17, 2001·Annals of Internal Medicine·C KearonJ Hirsh
Nov 28, 2001·British Journal of Haematology·M J KovacsP S Wells
Apr 3, 2002·Archives of Internal Medicine·James KellyBeverley J Hunt
Feb 26, 2003·Archives of Physical Medicine and Rehabilitation·Jay M MeythalerRobert C Brunner
Mar 26, 2003·Journal of Thrombosis and Thrombolysis·Job HarenbergMenno V Huisman
Apr 16, 2003·Journal of Clinical Laboratory Analysis·Rafael Noal MorescoRoberto Christ Vianna Santos
Apr 23, 2003·Thrombosis Research·Hyun Kyung KimChang-Min Kim
Aug 21, 2003·Clinical Chemistry·John E SchrecengostDavid E Bruns
Aug 28, 2003·JAMA : the Journal of the American Medical Association·Sabine EichingerPaul A Kyrle
Citations
Dec 13, 2006·Journal of Thrombosis and Thrombolysis·Rafael Noal MorescoLúcia Silla
Sep 18, 2010·Internal Medicine·Kazuhiro NagaokaHideki Tashiro
Oct 1, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Henriette A SelvikHalvor Næss
Jun 19, 2012·Thrombosis Research·Alhossain A KhalafallahTerry Brain
Oct 24, 2008·Thrombosis Research·Rafael Noal Moresco
Jul 12, 2014·Acta Clinica Belgica·H KaraB Ozturk
Feb 15, 2014·Journal of Wound Care·C ViennetP Humbert
Dec 17, 2008·International Heart Journal·Kiyohiro OshimaShigeru Saito
Jan 20, 2021·Hematological Oncology·Alberto FresaLuca Laurenti
Oct 31, 2020·Medicine·Nian ChenChuanlong Zhu