Association between platelet count and mucosal healing in Japanese patients with ulcerative colitis: a cross-sectional study.

BMC Gastroenterology
Shinya FurukawaYoichi Hiasa

Abstract

Mucosal healing (MH) has been indicated as the therapeutic goal for ulcerative colitis (UC). Platelet count is known as an inflammation evaluation. However, the association between platelet count and MH among patients with UC is still scarce. We therefore assessed this issue among Japanese patients with UC. The study subjects consisted of 345 Japanese patients with UC. Platelet count was divided into quartiles on the basis of the distribution of all study subjects (low, moderate, high, and very high). Several endoscope specialists were responsible for evaluating MH and partial MH, which was defined as a Mayo endoscopic subscore of 0 and 0-1, respectively. Estimations of crude odds ratios (ORs) and their 95% confidence intervals (CIs) for partial MH and MH in relation to platelet count were performed using logistic regression analysis. Age, sex, CRP, steroid use, and anti-Tumor necrosis factor α (TNFα) preparation were selected a priori as potential confounding factors. The percentage of partial MH and MH were 63.2 and 26.1%, respectively. Moderate and very high was independently inversely associated with partial MH (moderate: OR 0.40 [95%CI 0.19-0.810], very high: OR 0.37 [95%CI 0.17-0.77], p for trend = 0.034). Similarly, mode...Continue Reading

References

Dec 24, 1987·The New England Journal of Medicine·K W SchroederD M Ilstrup
May 23, 1998·Annual Review of Immunology·I S Grewal, R A Flavell
Mar 7, 2001·Cellular and Molecular Life Sciences : CMLS·U Schönbeck, P Libby
Mar 31, 2001·The American Journal of Gastroenterology·A N KapsoritakisE A Kouroumalis
Jun 6, 2007·International Journal of Colorectal Disease·Hasan KayahanHale Akpinar
Aug 8, 2007·Gastroenterology·Kathrine Frey FrøslieUNKNOWN IBSEN Group
Jul 29, 2009·Inflammatory Bowel Diseases·Gary R Lichtenstein, Paul Rutgeerts
Oct 13, 2009·Gastroenterology·Filip BaertUNKNOWN North-Holland Gut Club
Dec 2, 2009·Nature Reviews. Gastroenterology & Hepatology·Guillaume Pineton de ChambrunJean-Frédéric Colombel
Sep 24, 2011·Journal of Crohn's & Colitis·Laurent Peyrin-BirouletUNKNOWN Scientific Committee of the European Crohn's and Colitis Organization
Mar 9, 2013·Inflammatory Bowel Diseases·Triana LobatónJordi Guardiola
Jun 27, 2014·PloS One·Xin ZhouPing Liu
Feb 2, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Shailja C ShahNeeraj Narula
Mar 30, 2016·Gastroenterología y hepatología·Pablo Miranda-GarcíaJavier P Gisbert
Nov 30, 2018·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Mayu UchiharaMasayuki Kitano
Dec 26, 2018·Journal of Medical Biochemistry·Muhammet Yener AkpinarErtugrul Kayacetin

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