Association between platelet count as a noninvasive marker and ultrasonographic grading in patients with nonalcoholic Fatty liver disease

Hepatitis Monthly
Afagh GarjaniManouchehr Khoshbaten

Abstract

Nonalcoholic fatty liver disease has become a worldwide challenge. Liver biopsy remains the single most reliable approach to determine the severity of this disease. As patients with nonalcoholic fatty liver disease require close follow-up, performing this invasive method repeatedly seems impractical; therefore, designing a noninvasive system to follow up patients has become a common interest. We intended to investigate the association between platelet counts of patients with nonalcoholic fatty liver disease and the severity of their disease based on serum levels of liver enzymes and grade of fatty liver on ultrasonography. One thousand, three hundred and five patients with nonalcoholic fatty liver disease were included in this descriptive study. Serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and platelet counts of patients were measured. The grade of fatty liver was determined by abdominal ultrasonography. Of our study population, 54.3% (n = 708) were women. Patients with mild fatty liver on ultrasonography had lower platelet counts than those with moderate and severe fatty liver. However, no cutoff value of platelet count could reliably distinguish different grades ...Continue Reading

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Citations

May 27, 2016·Hepatitis Monthly·Mohammad Saeid Rezaee-ZavarehSeyed Moayed Alavian
Jun 6, 2015·Hepatitis Monthly·Kento ImajoAtsushi Nakajima
Dec 10, 2017·Obesity Surgery·Hans-Erik JohanssonArvo Haenni
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Dec 28, 2019·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·María Vanessa Bullón VelaJ Alfredo Martínez

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Methods Mentioned

BETA
biopsy

Software Mentioned

SPSS
Statistical Package for the Social Sciences
Minitab

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