Association between platelet distribution width and poor outcome of acute ischemic stroke after intravenous thrombolysis

Neuropsychiatric Disease and Treatment
Fan GaoJian-Feng Han

Abstract

The platelet distribution width (PDW) reflects the status of platelet activity and may be useful for early predictions of the clinical outcome of stroke patients. The purpose of the study was to determine the associations between PDW and clinical outcomes after intravenous thrombolysis in stroke patients. Acute ischemic stroke patients who received intravenous treatment with recombinant tissue-type plasminogen activator were selected for inclusion in the retrospective cohort of this study. The relations between PDW at admission and clinical outcomes were analyzed, including a poor outcome as assessed using the modified Rankin Scale at 3 months, early neurological improvement, and any hemorrhage. The effect of PDW at admission on a poor outcome at 3 months was analyzed using a multivariable logistic regression model with adjustment for potential confounders. The optimal PDW cutoff for predicting poor outcome at 3 months was determined by analyzing the receiver operating characteristics curve. PDW was significantly higher for a good outcome than a poor outcome (p=0.005), with median (interquartile range) values of 16.2 (13.2-17.2) and 13.6 (12.5-15.9), respectively. PDW was also higher in patients with early neurological improvem...Continue Reading

Citations

Apr 6, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Wang RuiyanZheng Tang
Apr 11, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Filipa Dourado SoteroPatrícia Canhão
Aug 3, 2021·Journal of Thrombosis and Haemostasis : JTH·Wobke E M van DijkKarin P M van Galen

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