Polyclonal and mixed mycobacterial Mycobacterium avium complex (MAC) infection is observed in pulmonary MAC disease. Human living environments contain multiple species or genotypes of nontuberculous mycobacterial strains and are considered sources of infection. To investigate the association of environmental exposure with polyclonal and mixed mycobacterial infection in pulmonary MAC disease after adjustments for potential confounding diseases and conditions and radiographic findings. We collected two separate sputum samples from 102 patients and single sputum samples from 18 patients in whom the second MAC strain was not isolated in our prospective cohort of pulmonary MAC disease. MAC isolates from sputum samples and patients' residential soils were used for variable number of tandem repeats (VNTR) analyses. Polyclonal and mixed mycobacterial MAC infections were defined as having different VNTR genotypes and other mycobacterial species, respectively. Monoclonal MAC infection was defined as all isolates showing a single VNTR genotype. Associations of the type of infection with clinical and radiographic findings and environmental exposure were measured. Polyclonal and mixed mycobacterial MAC and monoclonal infections were observe...Continue Reading
Polyclonal infections due to Mycobacterium avium complex in patients with AIDS detected by pulsed-field gel electrophoresis of sequential clinical isolates.
Bias of culture techniques for diagnosing mixed Mycobacterium genavense and Mycobacterium avium infection in AIDS.
Genetic diversity among strains of Mycobacterium avium causing monoclonal and polyclonal bacteremia in patients with AIDS
Use of different molecular typing techniques for bacteriological follow-up in a clinical trial with AIDS patients with Mycobacterium avium bacteremia.
The usefulness of a structured questionnaire in the assessment of symptomatic gastroesophageal reflux disease
Factors influencing numbers of Mycobacterium avium, Mycobacterium intracellulare, and other Mycobacteria in drinking water distribution systems
Repeat positive cultures in Mycobacterium intracellulare lung disease after macrolide therapy represent new infections in patients with nodular bronchiectasis
Optimization of procedures for isolation of mycobacteria from soil and water samples obtained in northern India
Investigation of spa pools associated with lung disorders caused by Mycobacterium avium complex in immunocompetent adults
Relationships between Mycobacterium isolates from patients with pulmonary mycobacterial infection and potting soils
An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases
Gastroesophageal reflux disease, acid suppression, and Mycobacterium avium complex pulmonary disease
The recovery of Mycobacterium avium-intracellulare complex (MAC) from the residential bathrooms of patients with pulmonary MAC
Pulmonary nontuberculous mycobacterial disease: prospective study of a distinct preexisting syndrome
Comparison of a variable-number tandem-repeat (VNTR) method for typing Mycobacterium avium with mycobacterial interspersed repetitive-unit-VNTR and IS1245 restriction fragment length polymorphism typing
Association between mycobacterial genotypes and disease progression in Mycobacterium avium pulmonary infection
Molecular typing of Mycobacterium intracellulare using multilocus variable-number of tandem-repeat analysis: identification of loci and analysis of clinical isolates
Nontuberculous mycobacterial lung disease prevalence at four integrated health care delivery systems
Nontuberculous mycobacterial infection as a cause of difficult-to-control asthma: a case-control study
Nontuberculous mycobacteria from household plumbing of patients with nontuberculous mycobacteria disease
Genetic relatedness of Mycobacterium avium-intracellulare complex isolates from patients with pulmonary MAC disease and their residential soils
Environment or host?: A case-control study of risk factors for Mycobacterium avium complex lung disease
Mycobacterial interspersed repetitive-unit-variable-number tandem-repeat (MIRU-VNTR) genotyping of mycobacterium intracellulare for strain comparison with establishment of a PCR-based database
Absence of Mycobacterium intracellulare and presence of Mycobacterium chimaera in household water and biofilm samples of patients in the United States with Mycobacterium avium complex respiratory disease
A novel approach to automated genotyping of Mycobacterium tuberculosis using a panel of 15 MIRU VNTRs
High-resolution computed tomography and health-related quality of life in Mycobacterium avium complex disease
The influence of environmental exposure on the response to antimicrobial treatment in pulmonary Mycobacterial avium complex disease
Impact of industrial structure and soil exposure on the regional variations in pulmonary nontuberculous mycobacterial disease prevalence
Recurrence of disseminated Mycobacterium avium complex disease in a patient with anti-gamma interferon autoantibodies by reinfection
Development of Macrolide Resistance and Reinfection in Refractory Mycobacterium avium Complex Lung Disease
Retrospective evaluation of natural course in mild cases of Mycobacterium avium complex pulmonary disease
Comparative Evaluation of Band-Based Genotyping Methods for Mycobacterium intracellulare and Its Application for Epidemiological Analysis
Assessment of soil features on the growth of environmental nontuberculous mycobacterial isolates from Hawai'i
Impact of different subspecies on disease progression in initially untreated patients with Mycobacterium avium complex lung disease.
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