Association between polymorphism of the G-protein β3 subunit C825T and essential hypertension: an updated meta-analysis involving 36,802 subjects

Biological Research
Huan ZhengMing Luo

Abstract

The G-protein β3-subunit gene C825T polymorphism (GNB3-C825T) has been reported to be associated with essential hypertension (EH), but results from previous studies are conflicting. The present study aimed at investigating the association between this polymorphism and risk of EH using a meta-analysis on the published studies. PubMed, Embase, CBM (China Biological Medicine Database), Wanfang and VIP databases were searched to identify eligible studies published in English and Chinese before March 2013. Data were extracted using standardized methods. The association was assessed by the odds ratio (OR) with 95% confidence intervals (CI). Begg's test was used to measure publication bias. A total of 40 case-control studies containing 16,518 EH patients and 20,284 controls were involved in this meta-analysis. Overall, a significant association was found between GNB3 C825T polymorphism and risk of EH when all studies were pooled with a random-effects model for T versus C (OR=1.09, 95% CI: 1.04-1.19). In the subgroup analysis, the same association was found in overall Caucasian (T versus C, OR=1.16, 95% CI 1.08-1.24) and Chinese populations (TT versus CC, OR=1.23, 95% CI 1.06-1.57). No associations were detected between GNB3-C825T and ...Continue Reading

Citations

Oct 11, 2014·Pharmacogenomics·Riccardo Lacchini, Jose E Tanus-Santos
Apr 9, 2016·Gastroenterology Research and Practice·Yi-Zuo SongQing-Ke Huang
Apr 24, 2015·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Andrea SempliciniGiulio Ceolotto
Nov 25, 2017·Scientific Reports·Ray Bahado-SinghKypros Nicolaides
May 27, 2016·Biomarker Insights·Neveen Salah El Din HemimiMona Mohamed Abdelsalam
Dec 29, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Jiajia SongZhangye Xu
Nov 9, 2021·Circulation·Seyedeh Maryam ZekavatPradeep Natarajan

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