Association between polymorphisms in the dopamine transporter gene and depression: evidence for a gene-environment interaction in a sample of juvenile detainees

Psychological Science
Gerald J HaeffelElena L Grigorenko

Abstract

Previous research has generated examples of how genetic and environmental factors can interact to create risk for psychopathology. Using a gene-by-environment (G x E) interaction design, we tested whether three polymorphisms in the dopamine transporter gene (DAT1, also referred to as SLC6A3, located at 5p15.33) interacted with maternal parenting style to predict first-onset episodes of depression. Participants were male adolescents (N= 176) recruited from a juvenile detention center in northern Russia. As hypothesized, one of the polymorphisms (rs40184) moderated the effect of perceived maternal rejection on the onset of major depressive disorder, as well as on suicidal ideation. Further, this G x E interaction was specific to depression; it did not predict clinically significant anxiety. These results highlight the need for further research investigating the moderating effects of dopaminergic genes on depression.

References

Jan 1, 1989·Annual Review of Psychology·R A Depue, W G Iacono
Nov 1, 1988·Journal of the American Academy of Child and Adolescent Psychiatry·D ShafferP Trautman
Jan 1, 1988·The American Journal of Psychiatry·J Bowlby
Apr 1, 1980·Acta Psychiatrica Scandinavica·C PerrisH Perris
Mar 1, 1994·Journal of Clinical Psychology·M L KaplanS Joseph
Apr 1, 1997·Current Opinion in Neurobiology·W Schultz
Mar 21, 1998·The Journal of Clinical Psychiatry·G B CassanoL Dell'Osso
Oct 22, 1998·Social Psychiatry and Psychiatric Epidemiology·V V RuchkinB Hägglöf
Dec 24, 1998·Journal of Clinical Psychopharmacology·N Bonhomme, E Esposito
Mar 12, 2002·Journal of the American Academy of Child and Adolescent Psychiatry·Vladislav V RuchkinHans Steiner
Jan 20, 2004·The Journal of Clinical Psychiatry·Paul E GreenbergPatricia K Corey-Lisle
Aug 25, 2005·Journal of Abnormal Psychology·Vladislav V RuchkinElena L Grigorenko
Sep 17, 2005·Psychological Medicine·Joshua L RoffmanScott L Rauch
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Camila GuindaliniGerome Breen
Mar 7, 2007·Archives of General Psychiatry·Boadie W Dunlop, Charles B Nemeroff
Mar 1, 2006·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Terrie E MoffittMichael Rutter

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Citations

Jan 13, 2011·Psychopharmacology·Nicole R NugentLawrence H Price
Feb 2, 2012·Development and Psychopathology·Daniel E AdkinsEdwin J C G van den Oord
Jun 19, 2009·Annual Review of Psychology·Dan P McAdams, Bradley D Olson
Jul 4, 2012·Indian Journal of Human Genetics·Anand TamatamAmarinder Singh Bawa
Jan 30, 2014·Annual Review of Clinical Psychology·Diego A Pizzagalli
Mar 2, 2011·Issues in Mental Health Nursing·Betty L Elder, Victoria Mosack
Mar 20, 2013·Molecular Aspects of Medicine·Akula Bala PramodL Keith Henry
Sep 15, 2015·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Emanuel SchwarzAndreas Meyer-Lindenberg
Apr 27, 2012·Biological Psychiatry·Yuliya S NikolovaAhmad R Hariri
Jan 7, 2016·Frontiers in Behavioral Neuroscience·Liangwei Xia, Shuqiao Yao
Jun 19, 2010·Progress in Neurobiology·Esther M OpmeerAndré Aleman
Mar 9, 2010·Psychoneuroendocrinology·Jaanus Harro, Evelyn Kiive
Mar 19, 2016·Journal of Affective Disorders·Stephanie D'SouzaKaren E Waldie
Sep 11, 2009·Journal of Traumatic Stress·Karestan C KoenenNicole R Nugent
Oct 1, 2011·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Erin C DunnKarestan C Koenen
Mar 9, 2012·Brain and Behavior·Andrea FeltenMartin Reuter
Feb 4, 2010·Aggressive Behavior·Elena L GrigorenkoCarolyn M Yrigollen
Mar 25, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Michael NguyenAllan V Kalueff
Jun 6, 2015·Depression and Anxiety·Long ZhaiDongfeng Zhang
Jul 28, 2013·Neuroscience and Biobehavioral Reviews·Laura Mandelli, Alessandro Serretti
Oct 16, 2014·Journal of Psychopharmacology·Roger M Lane
Mar 12, 2016·Cephalalgia : an International Journal of Headache·Yuanhao YangDale R Nyholt
Aug 3, 2017·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Angélica Salatino-OliveiraMara H Hutz
Mar 20, 2020·PloS One·Munn-Sann LyeNurul Asyikin Abdul Razak
Dec 29, 2020·Psychoneuroendocrinology·Rosana Carvalho SilvaAlessandra Minelli
Apr 15, 2009·Current Opinion in Psychiatry

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