Association between polymorphisms in the promoter regions of matrix metalloproteinases (MMPs) and risk of cancer metastasis: a meta-analysis.

PloS One
Dan LiuYun Bai

Abstract

A variety of studies have evaluated the associations between polymorphisms in the promoter regions of Matrix metalloproteinases (MMPs) and cancer metastasis. However, the results remain inconclusive. To better understand the roles of MMP polymorphisms in metastasis, we conducted a comprehensive meta-analysis. Electronic databases were searched (from January 2000 to June 2011) for any MMP genetic association studies in metastasis. Overall and subgroup analyses were performed. Odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the associations between MMP polymorphisms and metastasis. Statistical analysis was performed with Review Manager 5.0 and STATA11.0. Thirty-three studies addressing five MMP polymorphisms were analyzed among 10,516 cancer cases (4,059 metastasis-positive cases and 6,457 metastasis-negative cases). For MMP1 (-1607)1G/2G, genotype 2G/2G increased the overall risk of metastasis under the recessive model (OR = 1.44, 95% CI = 1.05-1.98). In subgroup analysis based on cancer type, associations were found in head/neck and breast cancer under the recessive model, and also in breast cancer under the dominant model. For MMP3 (-1171) 5A/6A, the polymorphism decreased the overall risk of metastasis ...Continue Reading

References

Sep 1, 1986·Controlled Clinical Trials·R DerSimonian, N Laird
Oct 6, 1997·BMJ : British Medical Journal·M EggerC Minder
Aug 26, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S Curran, G I Murray
Oct 5, 2002·Stroke; a Journal of Cerebral Circulation·Giorgio GhilardiRoberto Scorza
Jan 25, 2003·Journal of Biochemistry and Molecular Biology·Sang-Oh YoonAn-Sik Chung
Sep 13, 2003·Journal of the Society for Gynecologic Investigation·Robert M WenhamAndrew Berchuck
Nov 19, 2003·Nitric Oxide : Biology and Chemistry·Giorgio GhilardiRoberto Scorza
Feb 27, 2004·Journal of Cancer Research and Clinical Oncology·Shunji MatsumuraWataru Yasui
May 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Peter KripplHellmut Samonigg
Nov 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yi-Chin FongSean P Scully
Nov 27, 2004·Journal of Cancer Research and Clinical Oncology·Shunji MatsumuraWataru Yasui
Jun 14, 2005·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yimin WangJianhui Zhang
Nov 4, 2005·Breast Cancer Research and Treatment·Karolina PrzybylowskaJanusz Blasiak
Dec 15, 2005·International Journal of Cancer. Journal International Du Cancer·Pornchai O-charoenratSupatra Sangruchi
Dec 22, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Charles J Malemud
Jan 25, 2006·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·H-F TuT-Y Liu
Apr 20, 2006·Birth Defects Research. Part C, Embryo Today : Reviews·Vincent Lemaître, Jeanine D'Armiento
Jan 24, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Chun-Ying WuJaw-Town Lin
Jun 30, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Hela Ben NasrLotfi Chouchane
Oct 26, 2007·Journal of Negative Results in Biomedicine·Javier CotignolaIrene Orlow
Nov 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Simon HughesJ Louise Jones
Jun 10, 2009·International Journal of Cancer. Journal International Du Cancer·Peter McColgan, Pankaj Sharma
Jan 26, 2011·Journal of Gastroenterology and Hepatology·Kyung Sook ParkJin Cheon Kim
Feb 22, 2011·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Suhui WuJun Xie

❮ Previous
Next ❯

Citations

Mar 4, 2014·Journal of Translational Medicine·Zhou-Ji ZhangWei-Zhong Wu
Jan 30, 2014·Cancers·Antonietta Rosella Farina, Andrew Reay Mackay
Nov 16, 2013·PloS One·Noriaki YoshidaAkira Sakai
Sep 12, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xu-Yang XiaoDong-Yu Zang
May 30, 2014·Expert Review of Respiratory Medicine·Cory M YamashitaGregory P Downey
Oct 1, 2015·The Journal of Obstetrics and Gynaecology Research·Hong WangZhen-Yu Zhang
Sep 1, 2015·Archives of Medical Research·Zahra AdabiMandana Hasanzad
Jan 1, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Jiang HuZhi-Guo Luo
Feb 11, 2015·Matrix Biology : Journal of the International Society for Matrix Biology·Kai KessenbrockZena Werb
Apr 22, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xiaoli ZhangLinxi Zhang
Jul 5, 2016·Oxidative Medicine and Cellular Longevity·Gabriela Vilema-EnríquezJavier Camacho
Jul 29, 2016·Antioxidants & Redox Signaling·Debashree BasudharLisa A Ridnour
May 8, 2018·International Journal of Molecular Sciences·Supraja NarasimhanDavid H Sherr
Aug 18, 2018·Genetic Testing and Molecular Biomarkers·Yingcai LiWenzhi Song
Nov 8, 2018·DNA and Cell Biology·Weimin HuangRu Feng
Mar 8, 2018·International Journal of Oncology·Dalin DiJiyu Ju
May 27, 2020·Molecular and Clinical Oncology·Fawziya Abd Elmaogoud Ragab IbrahimNadia Ahmed Abd El Moneim
Mar 5, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Shafiul HaqueRaju K Mandal
Aug 20, 2016·Irish Journal of Medical Science·L Shajarehpoor SalavatiH K Manjili
Dec 1, 2019·Breast Cancer Research : BCR·Garhett L WyattTraci R Lyons

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Software Mentioned

STATA11
Review Manager
Embase
Google Scholar Search

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Cancer: Risk Factors

Breast cancer is a multifactorial disease that is influenced by both environmental and genetic factors. Discover the latest research on the environmental and genetic risk factors for breast cancer here.

Basement Membranes

Basement membranes are thin, specialized extracellular matrices surrounding most tissues in all metazoans. Here is the latest research on basement membranes.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.