Association between polymorphisms of arachidonate 12-lipoxygenase (ALOX12) and schizophrenia in a Korean population.

Behavioral and Brain Functions : BBF
Tae KimJoo-Ho Chung

Abstract

Arachidonic acid (AA), an essential polyunsaturated fatty acid, is one of the major components of neural membranes, which show an altered phospholipid composition in schizophrenia. Arachidonate 12-lipoxygenase (ALOX12), an important enzyme, metabolizes AA to 12-HPETE, which affects catecholamine synthesis. However, research has yet to show the genetic association between ALOX12 and schizophrenia. Therefore, we investigated single nucleotide polymorphisms (SNP) of the ALOX12 gene in schizophrenia, recruiting patients with schizophrenia (n = 289) and normal controls (n = 306) from a Korean population. We selected three SNPs (rs1126667, rs434473, and rs1042357) of the ALOX12 gene and genotyped them by direct sequencing. We reviewed the schizophrenic patients' medical records and assessed them clinically using the Brief Psychiatric Rating Scale (BPRS), the Scale for the Assessment of Negative Symptoms (SANS), and the Operational Criteria Checklist (OPCRIT). Then we statistically analyzed the genetic associations between the SNPs and schizophrenia, finding a genetic association between both rs1126667 and rs1042357 and schizophrenia, in the recessive model (p = 0.015 and 0.015, respectively). We also found an association between rs43...Continue Reading

Citations

Aug 7, 2012·Familial Cancer·Vidudala V T S Prasad, Kolli Padma
Aug 25, 2015·Redox Biology·Ryuichi Mashima, Torayuki Okuyama
Dec 2, 2014·Progress in Lipid Research·Thomas HornDagmar Heydeck
Mar 28, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Miri CarmelAbraham Weizman
Feb 25, 2011·The Journal of Clinical Endocrinology and Metabolism·Braxton D Mitchell, Laura M Yerges-Armstrong
Mar 1, 2011·Experimental and Therapeutic Medicine·Vidudala V T S PrasadDivya Moganti
Dec 3, 2017·International Urology and Nephrology·Athanasios K RoumeliotisPloumis S Passadakis
Jun 17, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhonghua ZhengShiwei Duan

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BETA
genotyping

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SeqMan
SNPStats

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