Association between polymorphisms of ERCC1 and survival in epithelial ovarian cancer patients with chemotherapy

Pharmacogenomics
Li YanSun Hai-Yan

Abstract

We evaluated whether the ERCC1 polymorphisms had an effect on survival in epithelial ovarian cancer (EOC) patients with platinum-based chemotherapy. Clinical data of 209 EOC patients between 2002 and 2008 were reviewed. The genotypes of 19007T/C and 8092C/A polymorphisms were assessed in all patients using PCR-RFLP. The 19007T/C polymorphism was significantly associated with response to treatment. Compared with the patients carrying C/C genotype, the patients with the T/T genotype have a significantly decreased response to platinum-based chemotherapy (odds ratio: 32.26; 95% CI: 3.66-250.00). Cox's multivariate analysis suggested that EOC patients with the T/T genotype had an increased risk of disease progression (hazard ratio: 3.34; 95% CI: 1.77-6.29) and death (hazard ratio: 2.87; 95% CI: 1.38-5.96) compared with those carrying the C/C genotype. The 19007T/C polymorphism may be a useful prognostic marker in patients with EOC treated with platinum-based chemotherapy in Chinese women.

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Citations

Jul 9, 2014·The Pharmacogenomics Journal·E CaiolaM Marabese
Sep 4, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Da-Qing ChenShu-Juan Yang
Feb 7, 2014·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Yan LiRong-miao Zhou
Sep 13, 2016·International Journal of Molecular Sciences·Vid MlakarMarc Ansari
Nov 3, 2017·Pharmacogenomics·Ricardo PintoRui Medeiros
Jan 24, 2019·Cancers·Giovanna Damia, Massimo Broggini

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Methods Mentioned

BETA
PCR
genotyping

Software Mentioned

SPSS

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