Association Between Potentially Inappropriate Medications and Frailty in the Early Old Age: A Longitudinal Study in the GAZEL Cohort

Journal of the American Medical Directors Association
P MartinotMarie Herr

Abstract

High-risk prescribing can have deleterious effects on the health of older people. This study aimed to assess the role of inappropriate prescribing on changes in frailty status over 3 years of follow-up. This is a prospective observational study nested in the GAZEL cohort. The study sample included 12,405 community-dwelling people aged 58 to 73 in 2012, and followed for 3 years. Polypharmacy and potentially inappropriate medications (PIMs) were assessed from reimbursement data by the French National Health Insurance. Frailty was evaluated each year with the Strawbridge questionnaire. PIMs were defined according to the Laroche list plus additional criteria dealing with inappropriate prolonged use of medications. The relationship between PIMs and changes in frailty status (incident frailty and recovery) was analyzed with Markov multistate modeling. The prevalence of frailty increased from 14% in 2012 to 17% in 2014, whereas the frequency of PIMs was 29% in 2012 and 23% in 2014. Polypharmacy (5-9 drugs: aHR 1.31, 95% CI 1.14-1.50; and 10 drugs or more: aHR 1.57, 95% CI 1.28-1.92) and potentially inappropriate use of nonsteroidal anti-inflammatory drugs (aHR 1.33, 95% CI 1.04-1.71) were significantly associated with incident frailty...Continue Reading

Citations

Oct 18, 2019·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Marta Gutiérrez-Valencia, Nicolás Martínez-Velilla
Oct 28, 2019·Journal of the American Geriatrics Society·Gulcan CilAndrew W Bergen
Jan 17, 2020·BMC Geriatrics·Solveig A ArnadottirUNKNOWN Pre-FIT Study Group
May 4, 2021·Journal of Pharmaceutical Health Care and Sciences·Yuya UragamiNaomi Iihara
Aug 28, 2021·Journal of Clinical Medicine·Encarnación Blanco-ReinaGabriel Ariza-Zafra
Sep 17, 2021·Expert Review of Pharmacoeconomics & Outcomes Research·Barbara RouxMarie-Laure Laroche

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